Zusammenfassung
Fortschritte in Methoden zur experimentellen und klinischen Erforschung verschiedenster Aspekte serotonerger Mechanismen haben zur Modifizierung früherer Konzepte des zentralen Serotoninsystems als eines vorwiegend „trophotropen“ Neurotransmitters geführt und klargestellt, daß die modulierenden Eigenschaften dieses expansiven und verbindungsreichen Neuronensystems in fast allen zentral regulierten Leistungen nachweisbar sind (Kognition, Lernen, Engrammbildung, Vigilanzsteuerung; Affekt-, Stimmungs- und Impulskontrolle; Sexual- und Sozialverhalten, Triebbefriedigungsverhalten, Alarmqualität von fremden Wahrnehmungsmustern, Schwellenempfindlichkeit für sensorische Stimulusmuster und für motorische Reflexreagibilität; Dynamik des motorischen Antriebspegels; Kreislauf- und Atemregulation; zirkadiane Organisation von neuroendokrinen Sekretionsprofilen, von Temperatur-, Aktivitäts- und Stimmungszyklen). Zur Sicherstellung so weitreichender Einflüsse auf kortexabhängige komplexe Funktionen hat sich das Serotoninsystem beim Primaten an die Evolution limbischer und sensorischer Kortizes angepaßt.
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Baumgarten, H.G. (1991). Neuroanatomie und Neurophysiologie des zentralen 5-HT-Systems. In: Heinrich, K., Hippius, H., Pöldinger, W. (eds) Serotonin — ein funktioneller Ansatz für die psychiatrische Diagnose und Therapie?. Die Reihe duphar med communication . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77192-7_2
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DOI: https://doi.org/10.1007/978-3-642-77192-7_2
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