Serotonin und Schlaf

  • Fritz Hohagen
  • Mathias Berger
Conference paper
Part of the Die Reihe duphar med communication book series (dmc)

Zusammenfassung

Über viele Jahre war man der Meinung, daß Schlaf ein einheitliches Stadium der Passivität sei, in dem alle Lebensfunktionen, also auch Stoffwechselvorgänge, auf ein Minimum reduziert seien. Spätestens seit den elektrophysiologischen Untersuchungen von Moruzzi u. Magoun (1949), Lindsley et al. (1949) und Nauta (1946) und durch die Befunde der Neurotransmitterforschung in den letzten 20 Jahren wissen wir, daß Schlaf ein aktiver Vorgang ist und daß die Aktivierung einzelner Neurotransmittersysteme eine wichtige Rolle in der Schlaf- Wach-Regulation darstellt. Seit den Untersuchungen von Jouvet (1969, 1 972) in den 60er Jahren steht das serotonerge System im Mittelpunkt der Schlafforschung, da Serotonin eine wichtige Rolle in der Schlaf-Wach-Regulationssteuerung zu spielen scheint.

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Literatur

  1. Adam K, Oswald I (1989) Effects of repeated ritanserin on middle-aged poor sleepers. Psychopharmacology 99:219—221PubMedCrossRefGoogle Scholar
  2. Adrien J, Hamon M (1989) Involvement of 5HT3 and 5HT1A Receptors in the control of sleep-wakefulness cycles in the cat. Sleep Res 18:29Google Scholar
  3. Bardeleben U von, Steiger A, Gerken A, Holsboer F (1986) Pharmacoendocrine and sleep-EEG characteristics of fluoxetine in normal controls. Br J Clin Pract [Suppl] 46:34–40Google Scholar
  4. Berger M, Emrich HM, Lund R, Riemann D, Lauer C, Zerssen D von (1985) Schlaf-EEG-Variablen als Verlaufskriterien und Prädiktoren einer Antidepressi- vatherapie mit Fluvoxamin/Oxaprotilin. In: Hippius H, Matussek N (Hrsg) Differentialtherapie der Depression: Möglichkeiten und Grenzen. Karger, München, S 120–131Google Scholar
  5. Borbély AA, Neuhaus HU, Tobler I (1981) Effect of p-chlorphenylalanine and tryptophan on sleep, EEG and motor activity in the rat. Behav Brain Res 2:1–22PubMedCrossRefGoogle Scholar
  6. Borbély AA, Trachsel L, Tobler I (1988) Effects of ritanserin on sleep stages and EEG in the rat. Eur J Pharmacol 156:275–278PubMedCrossRefGoogle Scholar
  7. Bradley PB, Engel G, Feniuk W et al (1986) Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology 25:563–576PubMedCrossRefGoogle Scholar
  8. Cespuglio R, Walker E, Gomez ME, Musolino R (1976) Cooling the nucleus raphe dorsalis induces sleep in the cat. Neurosci Lett 3:221–227PubMedCrossRefGoogle Scholar
  9. Clarenbach P, del Pozo E, Brownell J, Heredia E, Spiegel R, Cramer H (1980) Characterization of ergot and non-ergot serotinin antagonists by prolactin and growth hormone profiles during wakefulness and sleep. Brain Res 202:357–363PubMedCrossRefGoogle Scholar
  10. Clarenbach P, Birmanns B, Krätzschmar S, Jaursch-Hancke C (1986) Sleep pattern and nocturnal plasma profiles of HGH, prolactin and Cortisol in man after the serotonin-antagonist ritanserin and the GABA-agonist gabapentin. Sleep Res 15:29Google Scholar
  11. Cohen B, Ferguson J, Henriksen S, Stolk JM, Zarcone VJ, Barchas J, Dement W (1970) Effects of chronic depletion of brain serotonin on sleep and behavior. Proc Am Psychol Assoc 78:831–832Google Scholar
  12. Davenne D, Dugovic C, Franc B, Adrien J (1989) Ontogeny of slow wave sleep. In: Wauquier A et al (eds) Slow wave sleep: Physiological, pathophysiological and functional aspects. Raven, New York, pp 21–30Google Scholar
  13. De Roeck J, Cluydts R, Schotte C, Rouckhout D, Cosyns P (1989) Explorative single-blind study in the sedative and hypnotic effects of buspirone in anxiety patients. Acta Psychiatr Scand 79:129–135PubMedCrossRefGoogle Scholar
  14. De St. Hilaire-Kafi S, Gaillard JM (1988) Hypnotic action of flunitrazepam in the rat: does 5-HT mechanism play a role? Neuropharmacology 27:1227–1230PubMedCrossRefGoogle Scholar
  15. Declerck AC, Wauquier A, Ham-Veltman PHM van der, Gelders Y (1987) Increase in slow-wave sleep in humans with the serotinin-5-HT2 antagonist ritanserin (the first exploratory poly graphic sleep study). Curr Ther Res Clin Exp 41:427–432Google Scholar
  16. Delorme F, Fromment JL, Jouvet M (1966) Suppression du sommeil par la p- chloromethamphetamine et la p-chlorphenylalanine. Comp Rend Soc Biol 160:237–2351Google Scholar
  17. Deporteere H (1988) Effects of 5-HT1A-agonists on the sleep-wakefulness cycle in rats. In: Koella WP, Obäl F, Schulz H, Visser P (eds) Sleep 1986. Fischer, Stuttgart New York, pp 346–348Google Scholar
  18. Dugovic C, Wauquier A (1987) 5-HT2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat. Eur J Pharmacol 137:145–146PubMedCrossRefGoogle Scholar
  19. Dugovic C, Wauquier A, Leysen JE, Marrannes R, Janssen PAJ (1989 a) Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat. Psychopharmacology 97:436–442PubMedCrossRefGoogle Scholar
  20. Dugovic C, Leysen JE, Wauquier A (1989b) Melatonin modulates the sensitivity of 5-hydroxytrypramine-2 receptor-mediated sleep-wakefulness regulation in the rat. Neurosci Lett 104:320–325PubMedCrossRefGoogle Scholar
  21. Dzoljic MR, Saxena PR, Ukponmwan OE (1987) 5-HTx receptor agonists enhance alertness. Sleep Res 16:88Google Scholar
  22. Hobson JA, Marley RW, Wyzinski PW (1975) Sleep cycle oscillation. Reciprocal discharge by two brain stem neuronal groups. Science 189:55–58PubMedCrossRefGoogle Scholar
  23. Hobson JA, Lydic R, Baghdoyan HA (1986) Evolving concepts of sleep cycle generation: From brain centers to neuronal populations. Behav Brain Sci 9:371–448CrossRefGoogle Scholar
  24. Idzikowski C (1989) The effects of ritanserin and seganserin on human slow wave sleep. In: Wauquier A et al (eds) Slow wave sleep: Physiological, pathophysiological and functional aspects. Raven, New York, pp 97Google Scholar
  25. Idzikowski C, Mills FJ, Glennard R (1986) 5-Hydroxytryptamine-2-antagonist increases human slow wave sleep. Brain Res 378:164–168Google Scholar
  26. Jouvet M (1969) Biogenic amines and the states of sleep. Science 163:32–41PubMedCrossRefGoogle Scholar
  27. Jouvet M (1972) The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Rev Physiol 64:166–307Google Scholar
  28. Jouvet M (1983) Hypnogenic indolamine-dependent factors and paradoxical sleep rebound. In: Koella WP (ed) Sleep 1982. Karger, Basel, pp 2–18Google Scholar
  29. Jouvet M, Renault J (1966) Insomnie persistante après lesions des noyaux du raphé chez le chat. C R Soc Biol 160:1461–1465Google Scholar
  30. Koe BK, Weissman A (1966) p-Chlorophenylalanine: a specific depletor brain serotonin. J Pharmacol Exp Ther 154:499–516PubMedGoogle Scholar
  31. Koella WP (1985) Serotonin and sleep. In: Wauquier A et al (eds) Sleep: Neurotransmitters and neuromodulators. Raven, New York, pp 185–196Google Scholar
  32. Koella WP, Feldstein A, Czicman JS (1968) The effect of p-chlorophenylalanine on the sleep of cats. Electroencephalogr Clin Neurophysiol 25:481–490PubMedCrossRefGoogle Scholar
  33. Laguzzi R (1981) Effects de l’injection intraventriculaire de la méthiothépine et de la métergoline sur le sommeil du rat. CR Soc Biol 175:160–163Google Scholar
  34. Lerman JA, Kaitin KI, Dement WC, Peroutka SJ (1986) The effects of buspirone on sleep in the rat. Neurosci Let 72:64–68CrossRefGoogle Scholar
  35. Lindsley DB, Bowden LH, Magoun HW (1949) Effect upon the EEG of acute injury to the brain stem activating system. Electroencephalogr Clin Neurophysiol 1:475–486PubMedGoogle Scholar
  36. Minty DJ, Harper RM (1976) Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 101:569–575CrossRefGoogle Scholar
  37. Moruzzi G, Magoun HW (1949) Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1:445Google Scholar
  38. Nauta WJH (1946) Hypothalamus regulation of sleep in rats. Experimental study. J Neurophysiol 9:285–316PubMedGoogle Scholar
  39. Pack AT, Schmidt HS (1972) Methysergide and sleep in human subjects. Psychophysiology 9:88Google Scholar
  40. Paiva T, Arriaga F, Wauquier A, Lara E, Largo R, Leitao JN (1988) Effects of ritanserin on sleep disturbances of dysthymic patients. Psychopharmacology 96:395–399PubMedCrossRefGoogle Scholar
  41. Pappenheimer JR, Miller TB, Goodrich CA (1967) Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats. Proc Natl Acad Sci USA 58:513–517PubMedCrossRefGoogle Scholar
  42. Pieron H (1913) Le problème physiologique du sommeil. Masson, ParisGoogle Scholar
  43. Sallanon M, Buda C, Janin M, Jouvet M (1982) 5-HT antagonists suppress sleep and delay its restoration after 5-HTP in p-chlorophenylalanine-pretreated cats. Eur J Pharmacol 82:29–35PubMedCrossRefGoogle Scholar
  44. Sallanon M, Buda C, Janin M, Jouvet M (1985) Implication of serotonin in sleep mechanisms: induction, facilitation? In: Wauquier A et al (eds) Neurotransmitters and Neuromodulators. Raven, New York, pp 135–197+Google Scholar
  45. Smythe G A, Lazarus L (1974) Suppression of human growth hormone secretion by melatonin and cyproheptadine. J Clin Invest 54:116–121PubMedCrossRefGoogle Scholar
  46. Steiger A, Holsboer F, Guldner et al (1990) Effects of a 5-HT-3-receptor-antago- nist on sleep-EEG and sleep-associated hormonal secretion. 10th Congres of the european sleep research society. Abstracts book, Strasbourg, p 517)Google Scholar
  47. Tabushi K, Himwich HE (1971) Electroencephalographic study of the effects of methysergide on sleep in the rabbit. Electroencephalogr Clin Neurophysiol 31:491–497PubMedCrossRefGoogle Scholar
  48. Tissier MH, Franc B, Hamon M, Adrien J (1990) Effects of 5-HT-1A and 5-HT-3 receptor ligands on sleep in the rat. (10th Congress of the european sleep research society. Abstracts book, Strasbourg, p 348)Google Scholar
  49. Tortella FC, Echevarría E, Pastel RH, Cox B, Blackburn TP (1989) Suppressant effects of selective 5-HT2 antagonists on rapid eye movement sleep in rats. Brain Res 485:294–300PubMedCrossRefGoogle Scholar
  50. Weitzman ED, Rapport MM, Mregor P, Jacoby J (1968) Sleep patterns of the monkey and brain serotonin concentration: effect of p-chlorophenylalanine. Science 160:1361–1363PubMedCrossRefGoogle Scholar
  51. Wyatt RJ, Engelman K, Kupfer DJ, Scott J, Sjoerdsman A, Snyder F (1969) Effects of para-chlorophenylalanine on sleep in man. Electroencephalogr Clin Neurophysiol 27:529–532PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Fritz Hohagen
  • Mathias Berger

There are no affiliations available

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