Abstract
Assessment of airway dimensions based on the analysis of deposition and recovery of monodisperse aerosols in the respiratory tract during breath holding, originally introduced by Palmes et al. (1967), has recently been refined (single-breath aerosol recovery technique) and applied in spontaneously breathing normal human subjects (Heyder 1989) and in anesthetized, mechanically ventilated dogs with normal airway geometry (Rahmel et al., this volume). The technique has been demonstrated to facilitate the determination of effective airway diameters in vivo which were in close agreement with morphometric data of human and canine lungs.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Antonissen LA, Mitchell RW, Kroger EA, Kepron W, Stephens NL, Bergen J (1980) Histamine pharmacology in airway smooth muscle from a canine model of asthma. J Pharmacol Exp Ther 213:150–155
Barnes PJ, Basbaum CB, Nadel JA (1983) Autoradiographic localization of autonomic receptors in airway smooth muscle. Am Rev Respir Dis 127:758–762
Bates JHT, Baconnier P, Milic-Emili J (1988) A theoretical analysis of interrupter technique for measuring respiratory mechanics. J Appl Physiol 64:2204–2214
Colebatch HJM, Engel LA (1974) Constriction of the lung by histamine before and after adrenalectomy in cats. J Appl Physiol 37:798–805
Fredberg JJ, Ingram RH, Castile RG, Glass GM, Drazen JM (1985) Nonhomogeneity of lung response to inhaled histamine assessed with alveolar capsules. J Appl Physiol 58:1914–1922
Heyder J (1975) Gravitational deposition of aerosol particles within a system of randomly oriented tubes. Aerosol Sci 6:133–137
Heyder J (1989) Assessment of airway geometry with inert aerosols. J Aerosol Sci 2:89–97
Jaffrin MY, Kesic P (1974) Airway resistance: a fluid mechanical approach. J Appl Physiol 36:354–361
Kessler G-F, Austin JHM, Graf PD, Gamsu G, Gold WM (1973) Airway constriction in experimental asthma in dogs: tantalum bronchographic studies. J Appl Physiol 35:703–708
Mead J (1969) Contribution of compliance of airways to frequency-dependent behavior of lungs. J Appl Physiol 26:670–673
Meyer M, Slama H (1983) A versatile hydraulically operated respiratory servo system for ventilation and lung function testing. J Appl Physiol 55:1023–1030
Otis AB, McKerrow CB, Bartlett RA, Mead J, Mcllroy MB, Selverstone NJ, Radford EP (1956) Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol 8:427–443
Palmes ED, Altshuler B, Nelson N (1967) Deposition of aerosols in the human respiratory tract during breath holding. In: Davies CN (ed) Inhaled particles and vapours II. Pergamon, London, pp 339–347
Sellick H, Widdicombe JG (1971) Stimulation of lung irritant receptors by cigarette smoke, carbon dust, and histamine aerosol. J Appl Physiol 31:15–19
Shioya T, Solway J, Munoz NM, Mack M, Leff AR (1987) Distribution of airway contractile responses within the major diameter bronchi during exogenous bronchoconstriction. Am Rev Respir Dis 135:1105–1111
von Hayek H (1970) Die menschliche Lunge. Springer, Berlin Heidelberg New York
Yanta MA, Loring SH, Ingram RH, Drazen JM (1981) Direct and reflex bronchoconstriction by histamine aerosol inhalation in dog. J Appl Physiol 50:869–873
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Meyer, M., Rahmel, A. (1993). Assessment by Aerosol Recovery Technique of Site of Airway Constriction During Intravenous Histamine Challenge. In: Mohr, U., Bates, D.V., Fabel, H., Utell, M.J. (eds) Advances in Controlled Clinical Inhalation Studies. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77176-7_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-77176-7_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77178-1
Online ISBN: 978-3-642-77176-7
eBook Packages: Springer Book Archive