Assessment by Aerosol Recovery Technique of Site of Airway Constriction During Intravenous Histamine Challenge
Assessment of airway dimensions based on the analysis of deposition and recovery of monodisperse aerosols in the respiratory tract during breath holding, originally introduced by Palmes et al. (1967), has recently been refined (single-breath aerosol recovery technique) and applied in spontaneously breathing normal human subjects (Heyder 1989) and in anesthetized, mechanically ventilated dogs with normal airway geometry (Rahmel et al., this volume). The technique has been demonstrated to facilitate the determination of effective airway diameters in vivo which were in close agreement with morphometric data of human and canine lungs.
KeywordsDust Helium Sedimentation Histamine Smoke
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