Inhalation Studies with Airborne Particulates in Rodents: Cytotoxic and Genotoxic Effects on Alveolar Macrophages and Bone Marrow Cells

  • A. Kiell
  • W. Hadnagy
  • N. H. Seemayer
  • H. Behrendt
  • R. Tomingas
Conference paper
Part of the ILSI Monographs book series (ILSI MONOGRAPHS)


Industrialization, traffic, and urbanization are the most important factors causing contamination of the atmosphere with particulate and gaseous pollutants. These represent a very complex chemical mixture composed of several hundreds of mostly organic compounds (Helmes et al. 1982; Schlipkoter 1983). In previous studies it has been repeatedly reported that organic extracts are cytotoxic, mutagenic, and carcinogenic in a number of short-term bioassays using rodent and human tissue culture cells (Hadnagy et al. 1986, 1989; Motykiewiecz et al. 1991; Seemayer et al. 1984, 1988, 1989). Airborne particulates with a diameter of less than 5 μm are of special importance as they can reach the bronchoalveolar space in human lung by respiration. Macrophages in alveoli come into direct contact with noxious particles and gases as well as with diverse pathogenic microorganisms.


Surfactant Toxicity Dust Lactate Arsenic 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • A. Kiell
    • 1
  • W. Hadnagy
    • 1
  • N. H. Seemayer
    • 1
  • H. Behrendt
    • 1
  • R. Tomingas
    • 1
  1. 1.Medizinisches Institut f. UmwelthygieneHeinrich-Heine-UniversitätDüsseldorf 1Germany

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