Infectivity Models in Clinical Inhalation Studies

  • M. W. Frampton
Conference paper
Part of the ILSI Monographs book series (ILSI MONOGRAPHS)


The respiratory tract, because of its role in gas exchange, has a very large surface area in continuous contact with the atmosphere. Both atmospheric pollutants and infectious microorganisms gain access to the respiratory membrane, and it is reasonable to expect that inhaled toxic substances may interfere with the ability of the airways to defend against inhaled microorganisms. In fact, evidence exists from both epidemiologic observations and animal exposure studies supporting this hypothesis. However, questions remain about which pollutants and what levels of exposure are important, who is most susceptible, what kinds of infections are involved, and the mechanisms by which susceptibility is altered. This paper will examine the role of clinical inhalation studies in providing answers to these and other questions.


Influenza Virus Host Defense Nitrogen Dioxide Mucociliary Clearance Pollutant Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. W. Frampton
    • 1
  1. 1.Department of Medicine, Pulmonary and Critical Care UnitUniversity of Rochester Med. CenterRochesterUSA

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