Effect of Starvation on Brain Morphology and Function in Anorexia Nervosa and Bulimia Nervosa

  • J.-C. Krieg

Abstract

In the past several years there have been numerous studies on the neuroanatomical abnormalities of patients with psychiatric disorders, mainly using the method of computed tomography. This brain imaging technique enables in vivo examinations to be carried out with the aim of
  • Identifying structural brain alterations such as developmental abnormalities, local or global atrophy, and changes in brain density or signal intensity as a sign of histological alterations in the cerebral tissue;

  • Assessing functional abnormalities, for example, of the regional cerebral blood flow (CBF) or of the regional cerebral glucose metabolism as evidence for reduced neuronal activity.

Keywords

Depression Corticosteroid Dementia Cortisol Schizophrenia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Artmann H, Gall MV, Hacker H, Herrlich J (1981) Reversible enlargement of cerebral spinal fluid spaces in chronic alcoholics. Am J Neuroradiol 2: 23–27PubMedGoogle Scholar
  2. Bentson J, Reza M, Winter J, Wilson G (1978) Steroids and apparent cerebral atrophy on computed tomography scans. J Comput Assist Tomogr 2: 16–23PubMedCrossRefGoogle Scholar
  3. Carlen PL, Wortzman G, Holgate RC, Wilkinson DA, Rankin JG (1978) Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. Science 200: 1076–1078PubMedCrossRefGoogle Scholar
  4. Heinz ER, Martinez J, Haenggeli A (1977) Reversibility of cerebral atrophy in anorexia nervosa and Cushing’s syndrome. J Comput Assist Tomogr 1: 415–418PubMedCrossRefGoogle Scholar
  5. Herholz K, Krieg JC, Emrich HM, Pawlik G, Beil C, Pirke KM, Pahl JJ, Wagner R, Wienhard K, Ploog D, Heiss W-D (1987) Regional cerebral glucose metabolism in anorexia nervosa measured by positron emission tomography. Biol Psychiatry 22: 43–51PubMedCrossRefGoogle Scholar
  6. Jellinek EH (1962) Fits, faints, coma, and dementia in myxoedema. Lancet 3: 1010–1012CrossRefGoogle Scholar
  7. Kellner CH, Rubinow DR, Gold PW, Post RM (1983) Relationship of cortisol hypersecretion to brain CT scan alterations in depressed patients. Psychiatry Res 8: 191–197PubMedCrossRefGoogle Scholar
  8. Krieg J-C, Emrich HM, Backmund H, Pirke KM, Herholz K, Pawlik G, Heiss WD (1986) Brain morphology (CT) and cerebral metabolism (PET) in anorexia nervosa. In: Ferrari E, Brambilla F (eds) Disorders of eating behaviour. A psychoneuroendocrine approach. Pergamon, Oxford, p 247Google Scholar
  9. Krieg J-C, Pirke K-M, Lauer C, Backmund H (1988) Endocrine, metabolic, and cranial computed tomographic findings in anorexia nervosa. Biol Psychiatry 23: 377–387PubMedCrossRefGoogle Scholar
  10. Krieg J-C, Lauer C, Leinsinger G, Pahl J, Schreiber W, Pirke K-M, Moser EA (1989) Brain morphology and regional cerebral blood flow in anorexia nervosa. Biol Psychiatry 25: 1041–1048PubMedCrossRefGoogle Scholar
  11. Krieg J-C, Lauer C, Pirke K-M (1989) Structural brain abnoralities in patients with bulimia nervosa. Psychiatry Res 27: 39–48PubMedCrossRefGoogle Scholar
  12. Krieg J-C, Holthoff V, Schreiber W, Pirke KM, Herholz K (1991) Glucose metabolism in the caudate nuclei of patients with eating disorders, measured by PET. Eur Arch Psychiatry Clin Neurosci 240: 331–333PubMedCrossRefGoogle Scholar
  13. Laessle RG, Krieg JC, Fichter MM, Pirke KM (1989) Cerebral atrophy and vigilance performance in patients with anorexia nervosa and bulimia nervosa. Neuropsychobiology 21: 187–191PubMedCrossRefGoogle Scholar
  14. Lauer CJ, Lässle RG, Fichter MM, Pirke K-M, Krieg J-C (1990) Structural brain alterations and bingeing and vomiting behavior in eating disorder patients. Int J Eating Disord 9: 161–166CrossRefGoogle Scholar
  15. Lauer CJ, Krieg J-C, Riemann D, Zulley J, Berger M (1990) A polysomnographic study in young psychiatric inpatients: major depression, anorexia nervosa, bulimia nervosa. J Affective Disord 18: 235–245CrossRefGoogle Scholar
  16. Momose KJ, Kjellberg RN, Kliman B (1971) High incidence of cortical atrophy of the cerebral and cerebellar hemispheres in Cushing’s disease. Radiology 99: 341–348PubMedGoogle Scholar
  17. Okuno T, Ito M, Konishi Y, Yoshioka M, Nakano Y (1980) Cere-bral atrophy following ACTH therapy. J Comput assist Tomogr 4: 20–23PubMedCrossRefGoogle Scholar
  18. Pirke KM, Pahl J, Schweiger U, Wamhoff M (1985) Metabolic and endocrine indices of starvation in bulimia: a comparison with anorexia nervosa. Psychiatry Res 15: 33–39PubMedCrossRefGoogle Scholar
  19. Schlegel S, von Bardeleben U, Wiedemann K, Frommberger U, Holsboer F (1989) Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression. Psychoneuroendocrinol 14: 209–216CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J.-C. Krieg

There are no affiliations available

Personalised recommendations