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Zur Problematik der Risikoextrapolationam Beispiel von Dichlormethan (Methylenchlorid)

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Krebsrisiken am Arbeitsplatz

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Zusammenfassung

Ein im Rahmen des HdA-Programms bei uns durchgeführtes Vorhaben (FKZ: 01HK366/0) befaßte sich mit experimentell-toxikologischen Untersuchungen zum Mechanismus der Krebserzeugung durch Halomethane. Vornehmliches Ziel des Vorhabens war die Charakterisierung genotoxischer Eigenschaften von Chlormethan, Brommethan, Iodmethan und Dichlormethan sowie damit in Zusammenhang stehende Untersuchungen zum Metabolismus dieser Stoffe.

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Literatur

  1. Andersen ME, Clewell HJ, Gargas ML, Smith FA, Reitz RH (1987) Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol Appl Pharmacol 87:185–205

    Article  PubMed  CAS  Google Scholar 

  2. DFG (1986), Dichlormethan, Nachtrag 1986. In: Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten. Loseblattsammlung. VCH, Weinheim

    Google Scholar 

  3. van Door R, Borm PJA, Leijdekkers CM, Henderson PT, Reuvers J, van Bergen TJ (1988) Detection and identification of S-methylcysteine in urine of workers exposed to methyl chloride. Int Arch Occup Environ Health 46:99–109

    Article  Google Scholar 

  4. ECETOC (1987) Technical Report No. 26: The assessment of carcinogenic hazard for human beings exposed to methylene chloride. ECETOC, Bruxelles

    Google Scholar 

  5. ECETOC (1989) Technical Report No. 34: Methylene chloride (Dichloromethane): an overview of experimental work investigating species, differences in carcinogenicity and their relevance to man. ECETOC, Bruxelles

    Google Scholar 

  6. Gansewendt B, Deutschmann S, Schröder K, Hallier E (1990) Systemic genotoxocity of methyl bromide and methyl iodide in rats. Nauny-Schmiedeberg’s Arch Pharmacol [Suppl] 341:R28

    Google Scholar 

  7. Green T, Provan WM, Collinge DC, Guest AE (1988) Macromolecular interactions of inhaled methylene chloride in rats and mice. Toxicol Appl Pharmacol 93:1–10

    Article  PubMed  CAS  Google Scholar 

  8. Green T, Provan WM, Dugard PH, Cook SK (1988) ECETOC Technical Report No. 32: Methylene chloride (Dichloromethane) human risk assessment using experimental animal data. ECETOC, Bruxelles

    Google Scholar 

  9. Hallier E, Deutschmann S, Reichel C, Bolt HM, Peter H (1990) A comparative investigation of the metabolism of methyl bromide and methyl iodide in human erythrocytes. Int Arch Occup Environ Health 62:221–225

    Article  PubMed  CAS  Google Scholar 

  10. Hearne FT, Grase F, Pifer JW, Friedlander BR, Raleigh RL (1987) Methylene chloride mortality study: dose-response characterization and animal model comparison. J Occup Med 29:217–228

    PubMed  CAS  Google Scholar 

  11. IARC (1987) Monographs on the Evaluation of Carcinogenic Risks to Humans, Suppl 7. IARC, Lyon, pp 194–195

    Google Scholar 

  12. Kornbrust DJ, Bus J, Doerjer G, Swenberg JA (1982) Association of inhaled 14C-me-thyl chloride with macromolecules from various tissues. Toxicol Appl Pharmacol 65:122–134

    Article  PubMed  CAS  Google Scholar 

  13. Mirer EF, Silverstein M, Park R (1988) Letter to the editor. J Occup Med 30:475–476

    Article  PubMed  CAS  Google Scholar 

  14. NTP (1986) Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) in F 344/M rats and B6C3F1 mice. NTPTR 306, NIH Publ. No. 86-2562, US Dept. of Health and Human Services

    Google Scholar 

  15. Ottenwälder H, Peter H (1988) DNA binding assay of methylene chloride in rats and mice. Arch Toxicol 63:162–163

    Article  Google Scholar 

  16. Peter H, Laib RJ, Ottenwälder H, Topp H, Rupprich N, Bolt HM (1985) DNA binding assay of methylene chloride. Arch Toxicol 57:84–87

    Article  PubMed  CAS  Google Scholar 

  17. Peter H, Deutschmann S, Reichel C, Hallier E (1989) Metabolism of methyl chloride by human erythrocytes. Arch Toxicol 63:351–355

    Article  PubMed  CAS  Google Scholar 

  18. Reitz RH, Mendrala AL, Guengerich FP (1989) In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models. Toxicol Appl Pharmacol 97:230–246

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. M. Bolt
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Editors and Affiliations

  1. Bundesministerium für Arbeit und Sozialordnung, Postfach 140280, W-5300, Bonn 1, Bundesrepublik Deutschland

    A. Horst

  2. Institut für Hygiene und Arbeitsmedizin, des Universitätsklinikums Essen, Hufelandstr. 55, W-4300, Essen 1, Bundesrepublik Deutschland

    K. Norpoth

  3. Projektträgerschaft „Arbeit und Technik“, Deutsche Forschungsanstalt für Luft- und Raumfahrt (DLR), Südstr. 125, W-5300, Bonn 2, Bundesrepublik Deutschland

    C. Verkoyen

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© 1992 Springer-Verlag Berlin Heidelberg

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Bolt, H.M. (1992). Zur Problematik der Risikoextrapolationam Beispiel von Dichlormethan (Methylenchlorid). In: Horst, A., Norpoth, K., Verkoyen, C. (eds) Krebsrisiken am Arbeitsplatz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77128-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-77128-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54862-1

  • Online ISBN: 978-3-642-77128-6

  • eBook Packages: Springer Book Archive

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