Effects of Swelling on Glial Cell Function

  • H. K. Kimelberg
  • E. R. O’Connor
  • Helmut Kettenmann
Part of the Advances in Comparative and Environmental Physiology book series (COMPARATIVE, volume 14)


In the mammalian CNS astrocytic swelling is seen early in numerous pathological states such as ischemia (Jenkins et al. 1982), traumatic brain edema (Gerschenfeld et al. 1959; Castejon, 1980; Bullock et al. 1991), hypoglycemia and status epilepticus (Siesjo 1981), prolonged hypoxia (Yu et al. 1972), acute hypoxia with hypercapnia (Bakay and Lee 1968), hepatic encephalopathy and Reye’s syndrome (Norenberg 1981; Davis et al. 1990) and experimental allergic encephalomyelitis (Eng et al. 1989). Brain damage during these same pathological states is thought in many cases to be partly due to an inappropriate release of endogenous excitatory amino acids (EAAs) such as L-glutamate and L-aspartate. At the same time, extracellular K+ levels can reach 30–80mM (Somjen 1979; Sykova 1983).


Glial Cell Volume Regulation Kainic Acid Experimental Allergic Encephalomyelitis Regulatory Volume Decrease 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. K. Kimelberg
    • 1
    • 2
  • E. R. O’Connor
    • 2
  • Helmut Kettenmann
    • 3
  1. 1.Division of Neurosurgery A-60Albany Medical CollegeAlbanyUSA
  2. 2.Department of Pharmacology and ToxicologyAlbany Medical CollegeAlbanyUSA
  3. 3.Institut für Neurobiologie der Universität HeidelbergHeidelbergGermany

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