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Treatment of Vasculitides Affecting the Central Nervous System

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Vasculitis, Rheumatic Disease and the Nervous System
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Abstract

Vasculitis is being increasingly recognized as a cause of neurologic disease. The results of treatment vary from excellent to frustrating depending on the type of vasculitis, the etiology, and the stage of the disease. Some regimens in individual diseases dramatically reduce morbidity and mortality. In other disorders the optimal treatment remains empiric.

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References

  1. Budzilovich GN, Feigin I, Siegel H (1963) Granulomatous angiitis of the nervous system. Arch Pathol 76:250–256

    CAS  PubMed  Google Scholar 

  2. Campion EW (1992) Desperate diseases and plasmapheresis. N Engl J Med 326(21): 1425–1427

    Article  CAS  PubMed  Google Scholar 

  3. Caselli RJ, Hunder GG, Whisnant JP (1988) Neurologic disease in biopsy-proven giant cell (temporal) arteritis. Neurology 38:352–359

    Article  CAS  PubMed  Google Scholar 

  4. Clements PJ, Davis J (1986) Cytotoxic drags: their clinical applications to the rheumatic diseases. Semin Arthritis Rheum 15(4):231–254

    Article  CAS  PubMed  Google Scholar 

  5. Conn DL (1989) Subspeciality clinics: Rheumatology. Update on systemic necrotizing vasculitis. Mayo Clin Proc 64:535–543

    Article  CAS  PubMed  Google Scholar 

  6. Conn DL, Tompkins RB, Nichols WL (1988) Glucocorticoids in the management of vasculitis - a double edge sword? J Rheumatol 15:1181–1183

    CAS  PubMed  Google Scholar 

  7. DeRemee RA (1988) The treatment of Wegener’s granulomatosis with trimethoprim/sulfamethoxazole: illusion or vision? Arthritis Rheum 31(8): 1068–1072

    Article  CAS  PubMed  Google Scholar 

  8. De Vita SD, Bombardieri S (1991) Cyclophosphamide pulses in the treatment of rheumatic diseases: an update. Clin Exp Rheumatol 9:179–193

    PubMed  Google Scholar 

  9. Dietrich G, Kaveri SV, Kazatchkine MD (1992) Modulation of autoimmunity by intravenous immune globulin through interaction with the function of the immune/ idiotypic network. Clin Immunol Immunopathol 62: S73-S81

    Article  CAS  PubMed  Google Scholar 

  10. Fauci AS, Wolff SM (1973) Wegener’s granulomatosis: studies in eighteen patients and a review of the literature. Medicine 52:535–561

    Article  CAS  PubMed  Google Scholar 

  11. Fauci AS, Haynes BF, Costa J, Katz P, Wolff SM (1982) Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years. N Engl J Med 306:68–74

    Article  CAS  PubMed  Google Scholar 

  12. Frank MM, Basta M, Fries LF (1992) The effects of intravenous immune globulin on complement-dependent immune damage of cells and tissues. Clin Immunol Immunopathol 62:982–986

    Article  Google Scholar 

  13. Giulian D, Woodward J, Young DG, Krebs JF, Lachman LB Interleukin-1 injected into mamalian brain stimulates astrogliosis and neovascularization. J Neurosci 8:2485–2490 1988

    CAS  PubMed  Google Scholar 

  14. Guillevin L, Jarrousse B, Lok C, et al (1991) Longterm followup after treatment of polyarteritis nodosa and Churg-Strass angiitis with comparison of steroids, plasma exchange and cyclophosphamide to steroids and plasma exchange. A prospective randomized trial of 71 patients. J Rheumatol 18:567–574

    CAS  PubMed  Google Scholar 

  15. Hall S, Barr W, Lie JT, Stanson AW, Kazmier FJ, Hunder GG (1985) Takayasu arteritis. A study of 32 North American patients. Medicine 64(2):89–99

    Article  CAS  PubMed  Google Scholar 

  16. Hauptman HW, Ruddy S, Roberts WN (1991) Reversal of the vasospastic component of lupus vasculopathy by infusion of prostaglandin El. J Rheumatol 18:1747–1752

    CAS  PubMed  Google Scholar 

  17. Hoffman GS, Kerr GS, Leavitt RY, et al (1992) Wegener’s granulomatosis: an analysis of 158 patients. Ann Int Med 116(6):488–498

    Article  CAS  PubMed  Google Scholar 

  18. Hoffman GS, Leavitt RY, Fleisher TA, Minor JR, Fauci AS (1990) Treatment of Wegener’s granulomatosis with intermittent high-dose intravenous cyclophosphamide. Am J Med 89(4): 403–410

    Article  CAS  PubMed  Google Scholar 

  19. Holtman JH, Neustadt DH, Klein J, Callen JP (1990) Dapsone is an effective therapy for the skin lesions of subacute cutaneous lupus erythematosus and urticarial vasculitis in a patient with C2 deficiency. J Rheumatol 17(9): 1222–1225

    CAS  PubMed  Google Scholar 

  20. Hunder GG, Sheps SG, Allen GL, Joyce JW (1975) Daily and alternate-day corticosteroid regimes in treatment of giant cell arteritis. Comparison in a prospective study. Ann Int Med 82:613–618

    Article  CAS  PubMed  Google Scholar 

  21. Isaacs JD, Clark MR, Greenwood J, Waldmann H (1992) Therapy with monoclonal antibodies. J Immunol 148:3062–3071

    CAS  PubMed  Google Scholar 

  22. Jesus AD, Talal N (1990) Practical use of immunosuprressive drugs in autoimmune rheumatic diseases. Crit Care Med 18: S132–S137

    Article  PubMed  Google Scholar 

  23. Kahan BD (1989) Drug therapy. Cyclosporine. N Engl J Med 321:1725–1736

    Article  CAS  Google Scholar 

  24. Kanaide H, Takeshita A, Nakamura M (1982) Etiologic aspects of coagulopathy in Takayasu’s aortitis. Am Heart J 104:1039–1045

    Article  CAS  PubMed  Google Scholar 

  25. Kissel JT, Rammohan KW (1991) Pathogenesis and therapy of nervous system vasculitis. Clin Neuropharmacol 14:28–48

    Article  CAS  PubMed  Google Scholar 

  26. Leavitt RY, Hoffman GS, Fauci AS (1988) The role of trimethoprim/sulfamethoxazole in the treatment of Wegener’s granulomatosis. Arthritis Rheum 31:1073–1074

    Article  CAS  PubMed  Google Scholar 

  27. Mason WH, Jordan SC, Saki R, Takahashi M, Berstein B (1985) Circulating immune complexes in Kawasaki syndrome. Pediatr Infect Dis J 4:48

    Article  CAS  Google Scholar 

  28. Mathieson PW, Cobbold SP, Hale G, et al (1990) Monoclonal-antibody therapy in systemic vasculitis. N Engl J Med 323:250–254

    Article  CAS  PubMed  Google Scholar 

  29. Mathieu A, Carcassi U (1989) Cytotoxic drugs in systemic autoimmune diseases. Clin Exp Rheumatol 7/S3:181–186

    Google Scholar 

  30. McCune WJ, Golbus J, Zeldes W, Böhlke P, Dunne R, Fox DA (1988) Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus. N Engl J Med 318:1423–1431

    Article  CAS  PubMed  Google Scholar 

  31. Moore PM, Fauci AS (1981) Neurologic manifestations of systemic vasculitis. A retrospective and prospective study of the clinicopathologic features and responses to therapy in 25 patients. Am J Med 71:517–524

    Article  CAS  PubMed  Google Scholar 

  32. Neild GH, Ivory K, Williams DG (1984) Severe systemic vascular necrosis in cyclosporin-treatment rabbits with acute serum sickness. Br J Exp Pathol 65:731–743

    CAS  PubMed Central  PubMed  Google Scholar 

  33. Patton WF, Lynch JP (1982) Lymphomatoid granulomatosis. Clinicopathologic study of four cases and literature review. Medicine 61:1–12

    Article  CAS  PubMed  Google Scholar 

  34. Pirofsky B, Kinzey DM (1992) Intravenous immune globulins. A review of their uses in selected immunodeficiency and autoimmune diseases. Drugs 43:6–14

    Article  CAS  PubMed  Google Scholar 

  35. Scott DGI, Bacon PA (1984) Intravenous cyclophosphamide plus methylprednisolone in treatment of systemic rheumatoid vasculitis. Am J Med 76:377–384

    Article  CAS  PubMed  Google Scholar 

  36. Shelhamer JH, Voldman DJ, Parrillo JE, Lawley TJ, Johnston MR, Fauci AS (1985) Takayasu’s arteritis and its therapy. Ann Int Med 103:121–126

    Article  CAS  PubMed  Google Scholar 

  37. Vincent FM (1977) Granulomatous angiitis. N Engl J Med 296:452

    CAS  PubMed  Google Scholar 

  38. Yazici H, Pazarli H, Barnes CG, et al (1990) A controlled trial of azathioprine in Behget’s syndrome. N Engl J Med 322:281–285

    Article  CAS  PubMed  Google Scholar 

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© 1993 Springer-Verlag Berlin Heidelberg

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Moore, P.M., Gretz, N. (1993). Treatment of Vasculitides Affecting the Central Nervous System. In: Berlit, P., Moore, P.M. (eds) Vasculitis, Rheumatic Disease and the Nervous System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77122-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-77122-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54853-9

  • Online ISBN: 978-3-642-77122-4

  • eBook Packages: Springer Book Archive

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