Abstract
Pressure, like temperature, is one of the fundamental physical variables which constrain living entities. Because it is difficult to manipulate pressure as an experimental variable, however, it has not been a subject of casual study; indeed, very powerful motivation is required to pursue studies of pressure effects. Fortunately, the pressure domain does offer two strong motivations which apply particularly to the study of nerve cell behavior. As an experimental variable, pressure studies hold the promise of illuminating the physical changes undergone by membrane ion channels and other membrane components during normal nerve cell function, and also of probing the effects of anaesthetic agents. At the level of the functioning nervous system within the animal, pressure is one of the major environmental conditions to which organisms must accommodate as individuals or adapt as species. Some organisms cope with life cycles carried out at great depths and constant high pressure (Chap. 5). Some, including man, normally live near mean sea level pressure and dive occasionally; these must deal with the neurological effects of rapid pressure change. This chapter presents the contributions of pressure studies to understanding the way in which membrane proteins such as ion channels function. Those components most sensitive to pressure increases are highlighted, and the results presented in relation to changes in the behavior of isolated nerve cells and, ultimately, the whole nervous system.
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Kendig, J.J., Grossman, Y., Heinemann, S.H. (1993). Ion Channels and Nerve Cell Function. In: Macdonald, A.G. (eds) Effects of High Pressure on Biological Systems. Advances in Comparative and Environmental Physiology, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77115-6_3
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