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In vitro correlates of the pathogenicity of a long fibre sample of amosite asbestos compared to a short fibre sample

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Book cover Environmental Hygiene III

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Abstract

At the Institute of Occupational Medicine we have utilised two samples of amosite asbestos to study the role of fibre length in pathobiological activity. As shown in Table 1 these two samples, which differ only in length, are very different in their ability to cause tumours, fibrosis, inflammation and immunosuppression in animals exposed in vivo.

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References

  • Davis, J.M.G., Bolton, R.E., Donaldson, K., Jones, A.D., and Smith, T. (1986) The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp. Pathol. 67: 415–430.

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  • Donaldson, K., Szymaniec, S., Li, X.Y., Brown, D.M. and Brown, G.M. (in press) Inflammation and immunomodulation caused by short and long amosite asbestos samples. Proceedings of the International Workshop on Mechanisms of Fibre Carcinogenesis. Albuquerque, New Mexico, October 1990.

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  • Larrick, J.W. and Kunkel, S. (1988). The role of Tumour Necrosis Factor and Interleukin 1 in the immunoinflammatory response. Pharm. Res. 5: 129–139.

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Author information

Authors and Affiliations

  1. Institute of Occupational Medicine Ltd, 8 Roxburgh Place, Edinburgh, Scotland

    Kenneth Donaldson

Authors
  1. Kenneth Donaldson
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Editor information

Editors and Affiliations

  1. Medical Institute of Environmental Hygiene, University of Düsseldorf, Auf’m Hennekamp 50, 4000, Düsseldorf 1, Germany

    Norbert H. Seemayer  & Wolfgang Hadnagy  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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Donaldson, K. (1992). In vitro correlates of the pathogenicity of a long fibre sample of amosite asbestos compared to a short fibre sample. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77112-5_52

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  • DOI: https://doi.org/10.1007/978-3-642-77112-5_52

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77114-9

  • Online ISBN: 978-3-642-77112-5

  • eBook Packages: Springer Book Archive

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