In vitro correlates of the pathogenicity of a long fibre sample of amosite asbestos compared to a short fibre sample
At the Institute of Occupational Medicine we have utilised two samples of amosite asbestos to study the role of fibre length in pathobiological activity. As shown in Table 1 these two samples, which differ only in length, are very different in their ability to cause tumours, fibrosis, inflammation and immunosuppression in animals exposed in vivo.
KeywordsToxicity Dust Microbe Asbestos Carcinogenicity
Unable to display preview. Download preview PDF.
- Davis, J.M.G., Bolton, R.E., Donaldson, K., Jones, A.D., and Smith, T. (1986) The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp. Pathol. 67: 415–430.Google Scholar
- Donaldson, K., Brown, G.M., Bolton, R.E. (1988) The ability of inflammatory bronchoalveolar cell populations elicited with microbes or dust to injure alveolar epithelial cells and degrade extra-cellular matrix in vitro. Br. J. Exp. Pathol. 69: 327–388.Google Scholar
- Donaldson, K., Brown, G.M., Brown, D.M., Bolton, R.E. and Davis, J.M.G. (1989). The inflammation-generating potential of long and short fibre amosite asbestos samples. Br. J. Ind. Med. 46: 271–276.Google Scholar
- Donaldson, K., Szymaniec, S., Li, X.Y., Brown, D.M. and Brown, G.M. (in press) Inflammation and immunomodulation caused by short and long amosite asbestos samples. Proceedings of the International Workshop on Mechanisms of Fibre Carcinogenesis. Albuquerque, New Mexico, October 1990.Google Scholar