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The Behaviour of Inspired Aerosol Pulses in Men

  • Ch. F. Schiller-Scotland
  • J. Gebhart
  • R. Siekmeier
Conference paper

Abstract

Up to now the behaviour of inert aerosol particles within the human respiratory tract has primarily been studied in young healthy people. The application of bronchoconstrictive or brochodilatory pharmaca to this group results in a corresponding variation of aerosol derived effective airway dimensions (EADs). Each subject has been measured at least twice, once without pharmacon and then after drug application. By this way, each subject has been his own reference. It turned out that variations in EADs are most pronounced in proximal airways; the effect decreases continuously towards the lung periphery until it disappears. For the antagonistic drugs carbachol (bronchoconstrictor) and oxitropiumbromide ((VentilatR) bronchodilator) the sites of action are in almost identical volumetric lung depths VLDs. The percental changes in EADs are equivalent for the applied doses of pharmaca (Schiller-Scotland (1990)).

Keywords

Breathing Cycle Healthy Smoker Healthy Nonsmoker Human Respiratory Tract Proximal Airway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Schiller-Scotland, Ch.F., Gebhart, J., Scheuch, G., Siekmeier, R., Kronenberger, H. (1990): Human airway diameters derived from aerosol inhalation studies: Effect of inhaled drugs on airway dimensions. In: N.H. Seemayer, W. Hadnagy (Eds.): Environmental Hygiene II, Springer- Verlag, Berlin, pp. 229–232.Google Scholar
  2. Siekmeier, R., Gebhart, J., Kronenberger, H., Schiller-Scotland, Ch.F., Schultze-Werninghaus, G., Heyder, J., Meier-Sydow, J. (1990): Einfluß pharmakoninduzierter Bronchokonstriktion bzw. Bronchodilatation auf die Dispersion inhalierter Aerosolpulse. Atemwegs-Lungenkrankheiten 16, 289–291.Google Scholar
  3. Siekmeier, R., Gebhart, J., Kronenberger, H., Schiller-Scotland, Ch.F., Schmidt, U. (1991): Behaviour of inspired pulses of inert aerosol in middle-aged healthy smokers and non-smokers. J. Aerosol Medicine 4, Supplement 1, p. 43.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Ch. F. Schiller-Scotland
    • 1
  • J. Gebhart
    • 2
  • R. Siekmeier
    • 2
  1. 1.Institut für Biophysik der J.W.Goethe-UniversitätFrankfurt a.M.Germany
  2. 2.GSF Forschungszentrum für Umwelt und GesundheitD-Frankfurt a.M.Germany

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