Analysis of Transforming Sequences in Neoplastic Syrian Hamster Fetal Cells Induced by Diverse Chemical Carcinogens

  • V. Notario
  • N. Popescu
  • J. A. DiPaolo
Conference paper


Neoplastic transformation occurs with chemical carcinogens that interact with DNA such as carcinogenic polycyclic hydrocarbons, inorganic metals, N-Acetoxy-florenylacetamide and its derivatives and alkylating agents (1). Transformation resulting in malignancy also occurs with non-mutagenic agents including SO 2 (sodium bisulfite). With chemicals alone or in combination with X-irradiation the incidence of transformed hamster colonies fits a one hit curve indicating that the phenomenon is inductive (2).


Syrian Hamster Sodium Bisulfite Chemical Carcinogen Neoplastic Cell Line Syrian Hamster Embryo Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • V. Notario
    • 1
  • N. Popescu
    • 2
  • J. A. DiPaolo
    • 2
  1. 1.Department of Radiation MedicineGeorgetown University School of MedicineWashington, DCUSA
  2. 2.Laboratory of BiologyNCIBethesdaUSA

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