Abstract
Neoplastic transformation occurs with chemical carcinogens that interact with DNA such as carcinogenic polycyclic hydrocarbons, inorganic metals, N-Acetoxy-florenylacetamide and its derivatives and alkylating agents (1). Transformation resulting in malignancy also occurs with non-mutagenic agents including SO −2 (sodium bisulfite). With chemicals alone or in combination with X-irradiation the incidence of transformed hamster colonies fits a one hit curve indicating that the phenomenon is inductive (2).
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© 1992 Springer-Verlag Berlin Heidelberg
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Notario, V., Popescu, N., DiPaolo, J.A. (1992). Analysis of Transforming Sequences in Neoplastic Syrian Hamster Fetal Cells Induced by Diverse Chemical Carcinogens. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77112-5_22
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DOI: https://doi.org/10.1007/978-3-642-77112-5_22
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