Analysis of Transforming Sequences in Neoplastic Syrian Hamster Fetal Cells Induced by Diverse Chemical Carcinogens
Neoplastic transformation occurs with chemical carcinogens that interact with DNA such as carcinogenic polycyclic hydrocarbons, inorganic metals, N-Acetoxy-florenylacetamide and its derivatives and alkylating agents (1). Transformation resulting in malignancy also occurs with non-mutagenic agents including SO 2 − (sodium bisulfite). With chemicals alone or in combination with X-irradiation the incidence of transformed hamster colonies fits a one hit curve indicating that the phenomenon is inductive (2).
KeywordsSucrose Hydrate Agarose Electrophoresis Adduct
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