Abstract
Over the past 10 years, there have been a few studies of intra-arterial cisplatin (DDP) administration in patients affected by recurrent malignant intracerebral tumors [2–4, 6]. While the results were encouraging, there were still appreciable instances of systemic (oculo-, otho-, nephro-), and local (CNS) toxicity. The aim of this study was to try to reduce the systemic toxicity and augment the intraneo-plastic drug delivery.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Blalock JB, Wright DC, Dedrick TL et al. (1985) Drug streaming during intraarterial chemotherapy. Sixth International Conference on Brain Tumors Research, Ashville
Feun L, Wallace S, Stewart DJ et al. (1984) Intracarotid infusion of cis — diamminoedichloro-platinum in the treatment of recurrent malignant brain tumors. Cancer 54:794–799
Mahaley MS, Hipp SW, Dropcho EJ et al. (1989) Intracarotid cisplatin chemotherapy for recurrent gliomas. J Neurosurg 70:371–378
Neuwelt EA, Barnett PA, Glasberg et al. (1983) Pharmacology and neurotoxicity of cis-diamminoedichloroplatinum, bleomycin, 5-fluorouracil, and cyclophosphamide administration following osmotic blood-brain barrier modification. Cancer Res 43:5278–5285
Stewart DJ, Leavens M, Maor M et al. (1982) Human central nervous system distribution of cis-diamminoedichloroplatinum and use as a radiosensitiver in malignant brain tumors. Cancer Res 42:2474–2479
Stewart DJ, Wallace S, Feun L et al. (1982) A phase I study of intracarotid artery infusion of cis-diamminoedichlorplatinum (II) in patients with recurrent malignant intracerebral tumors. Cancer Res 42:2059–2062
Stewart DJ, Grahovac Z, Benoit B et al. (1984) Intracarotid chemotherapy with a combination of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), cis-diamminoedichloroplatinum (Cisplatin) and 4–0-demethyl-1–0-(4,6–0-2-thenylidene-β-D-glucopyranosyl) epipodophyllotoxin (VM26) in the treatment of primary and metastatic brain tumors. Neurosurgery 15:828–833
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Cristante, L., Siepmann, G., Westphal, M., Herrmann, HD. (1992). A Preliminary Study of Superselective Intra-arterial Cisplatin Infusion in the Treatment of Recurrent Malignant Gliomas. In: Piscol, K., Klinger, M., Brock, M. (eds) Neurosurgical Standards Cerebral Aneurysms Malignant Gliomas. Advances in Neurosurgery, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77109-5_48
Download citation
DOI: https://doi.org/10.1007/978-3-642-77109-5_48
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-54838-6
Online ISBN: 978-3-642-77109-5
eBook Packages: Springer Book Archive