A Preliminary Study of Superselective Intra-arterial Cisplatin Infusion in the Treatment of Recurrent Malignant Gliomas
Over the past 10 years, there have been a few studies of intra-arterial cisplatin (DDP) administration in patients affected by recurrent malignant intracerebral tumors [2–4, 6]. While the results were encouraging, there were still appreciable instances of systemic (oculo-, otho-, nephro-), and local (CNS) toxicity. The aim of this study was to try to reduce the systemic toxicity and augment the intraneo-plastic drug delivery.
KeywordsToxicity Hydration Anemia Dexamethasone Cyclophosphamide
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- 1.Blalock JB, Wright DC, Dedrick TL et al. (1985) Drug streaming during intraarterial chemotherapy. Sixth International Conference on Brain Tumors Research, AshvilleGoogle Scholar
- 7.Stewart DJ, Grahovac Z, Benoit B et al. (1984) Intracarotid chemotherapy with a combination of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), cis-diamminoedichloroplatinum (Cisplatin) and 4–0-demethyl-1–0-(4,6–0-2-thenylidene-β-D-glucopyranosyl) epipodophyllotoxin (VM26) in the treatment of primary and metastatic brain tumors. Neurosurgery 15:828–833PubMedCrossRefGoogle Scholar