A Preliminary Study of Superselective Intra-arterial Cisplatin Infusion in the Treatment of Recurrent Malignant Gliomas

  • L. Cristante
  • G. Siepmann
  • M. Westphal
  • H.-D. Herrmann
Part of the Advances in Neurosurgery book series (NEURO, volume 20)


Over the past 10 years, there have been a few studies of intra-arterial cisplatin (DDP) administration in patients affected by recurrent malignant intracerebral tumors [2–4, 6]. While the results were encouraging, there were still appreciable instances of systemic (oculo-, otho-, nephro-), and local (CNS) toxicity. The aim of this study was to try to reduce the systemic toxicity and augment the intraneo-plastic drug delivery.


Glioblastoma Multiforme Anaplastic Astrocytoma Malignant Brain Tumor Karnofsky Performance Score Recurrent Malignant Glioma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • L. Cristante
  • G. Siepmann
  • M. Westphal
  • H.-D. Herrmann
    • 1
  1. 1.Neurochirurgische AbteilungUniversitätskrankenhaus EppendorfHamburg 20Germany

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