Skip to main content

Correlation Between Cerebral Blood Flow Velocity in Basal Cerebral Arteries and Nimodipine Concentration in Serum and Plasma After Acute Subarachnoid Hemorrhage

  • Conference paper
Neurosurgical Standards Cerebral Aneurysms Malignant Gliomas

Part of the book series: Advances in Neurosurgery ((NEURO,volume 20))

  • 65 Accesses

Abstract

Calcium channel blockers are being used to an increasing extent in neurosurgery to prevent vasospasm and cerebral ischemia secondary to subarachnoid hemorrhage. However, results reported from open or placebo-controlled studies show a wide variation with regard to the outcome [3, 4, 11, 13–17].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aaslid R, Markwalder TM, Nomes H (1982) Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57:969–774

    Google Scholar 

  2. Aaslid R, Huber P, Nornes H (1984) Evaluation of the cerebrovascular spasm with transcranial Doppler ultrasound. J Neurosurg 60:37–41

    Article  PubMed  CAS  Google Scholar 

  3. Allen G, Ahn H, Preziosi T, Battye R, Boone S, Chou S, Kelly D, Weir B, Crabbe R, Mellits D, Bertsch L, Boisvert D, Hundley M, Johnson R, Strom J, Transou C (1983) Cerebral arterial vasospasm controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308:619–624

    Article  PubMed  CAS  Google Scholar 

  4. Auer LM (1983) Cerebrovascular activity of the calcium antagonist nimodipine. In: Reivich M, Hurtig HI (eds) Cerebrovascular disease. Raven Press, New York, pp 375–384

    Google Scholar 

  5. Auer LM, Ito Z, Suzuki A, Ohta H (1982) Prevention of symptomatic vasospasm by topically applied nimodipine. Acta Neurochir 63:297–302

    Article  CAS  Google Scholar 

  6. Cohen RJ, Allen GS (1980) Cerebral arterial spasm: the role of calcium in vitro and in vivo analysis of treatment with nifedipine and nimodipine. In: Wilkins RH (ed) Cerebral arterial spasm. Williams & Wilkins, Baltimore, pp 527–532

    Google Scholar 

  7. Espinosa F, Weir B, Scnitka T, Overton T, Boisvert D (1984) A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys. Part 2: Pathological findings. J Neurosurg 50:1176–1185

    Google Scholar 

  8. Giola E, White R, Bakhtian B, Robertson J (1985) Evaluation of the efficacy of intrathecal nimodipine in canine models of chronic cerebral vasospasm. J Neurosurg 62:721–728

    Article  Google Scholar 

  9. Hunt W, Hess R (1968) Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 28:14–19

    Article  PubMed  CAS  Google Scholar 

  10. Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. Lancet: 480–484

    Google Scholar 

  11. Kazner E, Sprung C, Adelt D, Ammerer HP, Karnick P, Baumann H, Böker DK, Grotenhuis JA, Jaksche H, Istaitih A (1985) Clinical experience with nimodipine in the prophylaxis of neurological deficits after subarachnoid hemorrhage. Neurochirurgia 28 (Suppl 1):110–113

    PubMed  Google Scholar 

  12. Kunz U, Seifert V, Stolke D, Dietz H (1987) Intrathecal administration of nimodipine for treatment of chronic cerebral vasospasm (an experimental study). In: Isamat F, Ferrer E (eds) Proc VIII European Congress of Neurosurg. Barcelona, Spain, p 277 (abstr)

    Google Scholar 

  13. Ljunggren B, Brandt L, Säveland H, Nilsson PE, Cronquist S, Andersson KE, Vinge E (1984) Outcome in 60 consecutive patients treated with early aneurysm operation and intravenous nimodipine. J Neurosurg 61:864–873

    Article  PubMed  CAS  Google Scholar 

  14. Ohman J, Heiskanen O (1988) Effect of nimodipine on the outcome of patients after aneurysmal subarachnoid hemorrhage and surgery. J Neurosurg 69:683–686

    Article  PubMed  CAS  Google Scholar 

  15. Petruk KC, West M, Mohr G, Weir B, Benoit B, Gentili F, Disney L, Khan M, Grace M, Holness R, Karwon M, Ford R, Cameron G, Tucker W, Purves G, Miller J, Hunter M, Richard M, Durity F, Chan R, Clein L, Maroun F, Godon A (1988) Nimodipine treatment in poor grade aneurysm patients. Results of a multicenter double blind placebo-controlled trial. J Neurosurg 68:505–517

    Article  PubMed  CAS  Google Scholar 

  16. Philippon J, Grob R, Dagreou F, Guggiari M, Rivierez M, Viars P (1986) Prevention of vasospasm in subarachnoid hemorrhage. A controlled study with nimodipine. Acta Neurochir 82:110–114

    Article  CAS  Google Scholar 

  17. Pickard J, Murray G, Illingworth R, Shaw M, Teasdale G, Foy P, Humphrey P, Lang D, Nelson R, Richards P, Sinar J, Bailey S, Skene A (1989) Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. Br Med J 298:636–642

    Article  CAS  Google Scholar 

  18. Raemsch KD, Graefe KH, Sommer J (1985) Pharmacokinetics and metabolism of nimodipine. In: Beth E, Deck K, Hoffmeister F (eds) Nimodipine, pharamcological and clinical properties. Schattauer, Stuttgart New York, pp 147–159

    Google Scholar 

  19. Steudel WI, Carvi y Nievas M, Tiyaworabun S, Lorenz R (1990) The prognostic significance of the concentration of nimodipine in the CSF and plasma in subarachnoid hemorrhage. In: Bushe KH, Brock M, Klinger M (eds) Advances in neurosurgery, vol 18. Springer, Berlin Heidelberg New York Tokyo, pp 180–184

    Google Scholar 

  20. Takayasu M, Bassett JE, Dacey RG Jr (1988) Effects of calcium antagonists on intracerebral penetrating arterioles in rats. J Neurosurg 69:104–109

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 pringer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Rosenthal, D., y Nievas, M.C., Steudel, W.I., Ricco, A., Lorenz, R. (1992). Correlation Between Cerebral Blood Flow Velocity in Basal Cerebral Arteries and Nimodipine Concentration in Serum and Plasma After Acute Subarachnoid Hemorrhage. In: Piscol, K., Klinger, M., Brock, M. (eds) Neurosurgical Standards Cerebral Aneurysms Malignant Gliomas. Advances in Neurosurgery, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77109-5_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77109-5_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54838-6

  • Online ISBN: 978-3-642-77109-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics