Methods for Manipulation of Regional Brain Perfusion, Intracranial Artery Diameter, and Cerebral Blood Volume

  • L. Friberg
Conference paper


A number of basically different methods are used to study the human cerebral circulation. No single method can reveal a complete picture of all the intracranial vascular changes and mechanisms which can be induced by physiological or pharmacological stimulation. In that sense each set of findings is linked to the method used.


Single Photon Emission Computerize Tomography Cerebral Blood Volume Regional Cerebral Blood Flow Cereb Blood Flow Scalp Cool 
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  1. Aaslid R (1986) Transcranial Doppler sonography. Springer, Berlin Heidelberg New YorkGoogle Scholar
  2. Andersen AR, Friberg HH, Schmidt JF, Hasselbalch SG (1988) Quantitative measurements of cerebral blood flow using SPECT and 99m-Tc-d, l-Hm-PAO compared to xenon-133. J Cereb Blood Flow Metab 8:S69-S81PubMedCrossRefGoogle Scholar
  3. Bolmsjö MS (1984) Hemisphere cross talk and signal overlapping in bilateral regional cerebral blood flow measurements using Xe-133. Eur J Nucl Med 9:1–5PubMedCrossRefGoogle Scholar
  4. Conrad B, Klingelhöfer J (1989) Dynamics of regional cerebral blood flow for various visual stimuli. Exp Brain Res 77:437–441PubMedCrossRefGoogle Scholar
  5. Dahl A, Rassel D, Nyberg-Hansen R, Rootwelt K (1989) Effect of nitroglycerine on cerebral circulation measured by transcranial Doppler and SPECT blood flow studies. Stroke 20:1733–1736PubMedCrossRefGoogle Scholar
  6. Friberg L (1989) Effects of a new 5-HTl-like receptor agonist, GR43175, on the regional brain tissue perfusion and intra-cerebral artery tone regulation in healthy volunteers. Cephalalgia [Suppl 10] 9:359–360Google Scholar
  7. Friberg L (1991) Cerebral blood flow changes in migraine: methods, observations and hypothesis. J Neurol 238:S12-S17PubMedCrossRefGoogle Scholar
  8. Friberg L, Roland PE (1988) Functional activation and inhibition of regional cerebral blood flow and metabolism. In: Olesen J, Edvinsson L (eds) Basic mechanisms of headache. Elsevier, Amsterdam, pp 89–98Google Scholar
  9. Friberg L, Kastrup J, Hansen M, Bülow J (1986) Cerebral effects of scalp cooling and extracerebral contribution to calculated blood flow values using the intravenous 133-Xe technique. Scand J Clin Lab Invest 46:375–379PubMedCrossRefGoogle Scholar
  10. Friberg L, Kastrup J, Rizzi D, Jensen JB, Lassen NA (1990 Cerebral blood flow and end tidal pC02 during prolonged acetazolamide treatment in man. Am J Physiol H954-H959Google Scholar
  11. Friberg L, Olesen J, Iversen H, Sperling B (1991) Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan. Lancet 338:13–17PubMedCrossRefGoogle Scholar
  12. Holm S, Friberg L, Iversen HK, Lassen NA (1990) Dual energy brain SPECT - methods and applications. In: Schmidt HAE, Chambron J (eds) Nuclear medicine: quantiative analysis in imaging and function. Schattauer, Stuttgart, pp 11–13Google Scholar
  13. Iversen HK, Holm S, Friberg L (1989) Intracranial hemodynamics during intravenous nitroglycerine infusion. Cephalalgia [Suppl 10] 9:84–85Google Scholar
  14. Jensen JB, Friberg L, Chiara SD, Lassen NA (1987) Changes in CBF during acute and prolonged administration of theophylline. J Cereb Blood Flow Metab [Suppl 1] 7:S276Google Scholar
  15. Kelbaek H (1986) Technetium-99m labeling of red blood cells: in vitro evaluation of a new approach. J Nucl Med 27:1770–1773PubMedGoogle Scholar
  16. Lassen NA, Andersen AR, Friberg L, Paulson OB (1988) The retention of [99mTc]-d, 1-HMPAO in the human brain after intracarotid bolus injection: a kinetic analysis. J Cereb Blood Flow Metab 8.S13-S22PubMedCrossRefGoogle Scholar
  17. Lassen NA, Ingvar DH, Raichle ME, Friberg L (eds) (1991) Brain work and mental activity: Quantitative studies with radioactive tracers. Munksgaard, Copenhagen, pp 1–443.Google Scholar
  18. Lebran-GrandiPe P, Baron J-C, Soussaline F, Loch’h C, Sastre J, Bousser M-G (1983) Coupling between regional cerebral blood flow and oxygen utilization in the normal human brain. Arch Neurol 40:230–236Google Scholar
  19. Madsen PL, Schmidts JF, Wildschiødtz G, Friberg L, Holm S, Vorstrup S, Lassen NA (1991a) Cerebral 02 metabolism and cerebral blood flow in humans during deep and rapid eye movement sleep. J Appl Physiol 70:2597–2601PubMedGoogle Scholar
  20. Madsen PL, Holm S, Vorstrup S, Friberg L, Lassen NA, Wildschiødtz G (1991b) Human regional cerebral blood flow during rapid eye movement sleep 7 Cereb Blood Flow Metab 11:502–507Google Scholar
  21. Neirinckx RD, Burke JF, Harrison RC, Forster AM, Andersen AR, Lassen NA (1988) The retention mechanism of technetium-99m-HM-PAO: intracellular reaction with glutathione. J Cereb Blood Flow Metab 8:S4-S12PubMedCrossRefGoogle Scholar
  22. Obrist WD, Wilkinson WE (1990) Regional cerebral blood flow measurement in humans by Xenon-133 clearance. Cerebrovasc brain Metab Rev 2:283–327PubMedGoogle Scholar
  23. Raichle ME, Grubb RL, Gado MH, Eichling JO, Ter-Pogossian MM (1976) Correlation between regional cerebral blood flow and oxidative metabolism. Arch Neurol 33:523–526PubMedGoogle Scholar
  24. Roland PE (1981) Somatotopic tuning of the postcentral gyrus during focal attention in man. A regional cerebral blood flow study. J Neurophysiol 46:744–754PubMedGoogle Scholar
  25. Roland PE, Friberg L (1985) Localization of cortical areas activated by thinking. J Neurophysiol 53:1219–1243PubMedGoogle Scholar
  26. Roland PE, Friberg L (1988) The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance. J Cereb Blood Flow Metab 8:314–323PubMedCrossRefGoogle Scholar
  27. Roland PE, Eriksson L, Stone-Elander S, Widen L (1987) Does mental activity change oxidative metabolism of the brain? J Neurosci 7:2373PubMedGoogle Scholar
  28. Rubin P, Holm S, Friberg L, Videbaek P, Andersen HS, Bjerg-Bentsen B, Strømsø N, Larsen JK, Lassen NA, Hemmingsen R (1991) Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophrenia and schizophreniform disorder: a regional cerebral blood flow study. Arch Gen Psychiatr 48: 987–995.PubMedGoogle Scholar
  29. Vorstrup S, Henriksen L, Paulson OB (1984) Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen. J Clin Invest 74:1634–1639CrossRefGoogle Scholar

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© Springer-Verlag, Berlin Heidelberg 1992

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  • L. Friberg

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