Abstract
Perfusion reserve is recruited to balance organ perfusion versus systemic changes in blood pressure. Regionally, recruitment is of special interest since it acts (a) to maintain baseline perfusion (or flow) in decreasing perfusion pressure (e.g., beyond a stenosis) or (b) to meet increased metabolic demands of an organ during exercise or any other stimulus (Buell and Schicha 1990). Cerebral perfusion reserve (CPR) is a complex system, comprising cerebral perfusion or blood flow (CBF), cerebral blood volume, blood thixotrophy, adaptions in peripheral hematocrit (Schmid-Schonbein 1988), oxygen carriage, chemical effects, vascular innervation and tone (Aaslid et al. 1989), and hormonal and endothelial factors. The vascular reaction to CO2, for example, measured with laser Doppler in normal cat brain revealed a 19% increase in pial arteriolar diameter in combination with augmented flow of 70% and flow velocity of 60%. Blood volume increased by 10% (Haberl et al. 1989). In acute or chronic cerebrovascular disease, CPR seems to recruit these determinants in different combinations. For acute disorders, the interactions have been described by Frackowiak and Wise (1983) and, most recently, by Arora et al. (1990). This article considers findings in chronic cerebrovascular disease.
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© 1992 Springer-Verlag, Berlin Heidelberg
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Buell, U. et al. (1992). Cerebral Blood Flow to Cerebral Blood Volume Relationship as a Correlate to Cerebral Perfusion Reserve. In: Schmiedek, P., Einhäupl, K., Kirsch, CM. (eds) Stimulated Cerebral Blood Flow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77102-6_13
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DOI: https://doi.org/10.1007/978-3-642-77102-6_13
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