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Changes and Clinical Correlations of P300 in Schizophrenia

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Imaging of the Brain in Psychiatry and Related Fields

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Abstract

A significantly reduced amplitude of the P300 component of the eventrelated potential (ERP) in schizophrenic patients has frequently been reported and is considered to be characteristic of schizophrenia. However, there are several other questions that remain concerning other parameters of the ERP and the clinical relevance of the changes (Blackwood et al. 1987; Pfefferbaum et al. 1989; Pritchard 1986). The present study tries to clarify two questions in P300 research in schizophrenia: (1) Is P300 latency prolonged in schizophrenic patients? (2) Are there relationships between P300 amplitude/latency and clinical symptoms of schizophrenia?

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References

  • Blackwood DH, Whalley LJ, Christie JE, Blackburn IM, St Clair DM, Mclnnes A (1987) Changes in auditory P3 event-related potential in schizophrenia and depression. Br J Psychiatry 150:154–160

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  • Pfefferbaum A, Ford JM, White PM, Roth WT (1989) P3 in schizophrenia is affected by stimulus modality, response requierements, medication status, and negative symptoms. Arch Gen Psychiatry 46:1035–1044

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  • Pritchard WS (1986) Cognitive event-related potential correlates of schizophrenia. Psychol Bull 100:43–66

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Author information

Authors and Affiliations

  1. Klinik für Allg. Psychiatrie, Universitätsklinikum Essen, Hufelandstr. 55, W-4300, Essen, Germany

    G. Eikmeier

Authors
  1. G. Eikmeier
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  2. E. Lodemann
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  3. H. M. Olbrich
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  4. D. Zerbin
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  5. M. Gastpar
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Würzburg, Füchsleinstr. 15, W-8700, Würzburg, Germany

    Konrad Maurer M.D. (Professor of Psychiatry, Neurology, Psychotherapy) (Professor of Psychiatry, Neurology, Psychotherapy)

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© 1993 Springer-Verlag Berlin Heidelberg

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Eikmeier, G., Lodemann, E., Olbrich, H.M., Zerbin, D., Gastpar, M. (1993). Changes and Clinical Correlations of P300 in Schizophrenia. In: Maurer, K. (eds) Imaging of the Brain in Psychiatry and Related Fields. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77087-6_36

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  • DOI: https://doi.org/10.1007/978-3-642-77087-6_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77089-0

  • Online ISBN: 978-3-642-77087-6

  • eBook Packages: Springer Book Archive

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