A New Methodical Approach for the Imaging of Cerebral Benzodiazepine Receptors in Schizophrenia: Preliminary Results of a Single Photon Emission Tomography Study with [123I] Iomazenil

  • J. Schröder
  • B. Bubeck
  • U. Roelcke
  • M. Jauss
  • P. A. Schubiger
  • H. Sauer

Abstract

Hunkeler et al. (1981) were the first to describe the potent benzodiazepine antagonist flumazenil (Ro 15–1788). This substance was labeled with positron emitters for positron emission tomography (PET) studies (Maziere et al. 1984). To make benzodiazepine receptor imaging possible with single photon emission tomography (SPET), a common technique in nuclear medicine, Beer et al. (1990) labeled an analogue of flumazenil with iodine-123. This new radiopharmaceutical, iomazenil (Ro 16–0154), has been used in a European multicenter study involving mainly epileptics (Schubiger and Hasler 1990).

Keywords

Ethyl Iodine Cortisol Schizophrenia Serotonin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. Schröder
    • 1
  • B. Bubeck
  • U. Roelcke
  • M. Jauss
  • P. A. Schubiger
  • H. Sauer
  1. 1.Abt. für Psychiatrie und Nukleare MedizinUniversität HeidelbergHeidelbergGermany

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