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Biologische Psychiatrie pp 215–218Cite as

Neuronale Membran-Angriffsmechanismen am Beispiel von Phosphatidylserin und S-Adenosyl-Methionin

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Zusammenfassung

Eine der Hauptstrategien bei der Entwicklung neuer Psychopharmaka während der letzten Jahre war die Suche nach neuen Substanzen mit immer spezifischeren und selektiveren molekularen Wirkungsmechanismen. Beispiele dafür sind die hochselektiven Serotonin-Wiederaufnahme-Inhibitoren aus dem Bereich der Antidepressiva, die 5-HT1A-Agonisten aus dem Bereich der Anxiolytika, oder die Suche nach hochselektiven zentral-wirksamen M1-Agonisten zur Therapie der Demenz. Im direkten Kontrast zu diesen neuen therapeutischen Ansätzen, die auf eine hochspezifische Beeinflussung nur eines selektiven Parameters im Bereich eines spezifischen Transmitter-systems abzielen, stehen zwei neuere Substanzen (S-Adenosyl-Methionin und Phosphatidylserin), die relativ unselektiv allgemeine Funktionen der Nervenzelle beeinflussen, wobei beide Substanzen möglicherweise über eine Modifikation der Eigenschaften der neuronalen Membran in zentralnervöse Funktionen eingreifen.

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Literatur

  • Amaducci L (1988) Phosphatidylserine in the treatment of Alzheimer’s disease: results of multi-center study. Psychopharmacol Bull 24: 130–134

    PubMed  CAS  Google Scholar 

  • Baldessarini RJ (1987) Neuropharmacology of S-Adenosyl-L-Methionine. Am J Med 83 (Supp l5A): 95–103

    Article  PubMed  CAS  Google Scholar 

  • Calderini G, Aporti F, Bellini F et al. (1985) Phospholipids as pharmacological tools in the aging brain. In: Horrocks LA (ed) Phospholipids in the nervous system, Vol 2. Raven Press, New York, pp 11–19

    Google Scholar 

  • Calderini G, Bellini F, Bonetti AC et al. (1987) Pharmacological properties of phosphatidylserine in the ageing brain. Clin Trials J 24: 9–17

    Google Scholar 

  • Carney MWP (1986) Neuropharmacology of S-Adenosyl-Methionine. Clin Neuropharmacol 9: 235–243

    Article  PubMed  CAS  Google Scholar 

  • Cimino M, Vantini G, Algeri S, Curatola G, Pezzoli C, Stramentinoli G (1984) Age-related modification of dopaminergic and β-adrenergic receptor system: Restoration to normal activity by modifying membrane fluidity with S-Adenosylmethionine. Life Sei 34: 2029–2039

    Article  CAS  Google Scholar 

  • Cohen BM, Satlin A, Zubenko G (1988) S-Adenosyl-L-methionine in the treatment of Alzheimer’s disease. J Clin Psychopharmacol 8: 43–47

    PubMed  CAS  Google Scholar 

  • Crook T, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Casade Massari D (1991) Effects of phosphatidylserine in age-associated memory impairment. Neurology 41: 644–649

    PubMed  CAS  Google Scholar 

  • Denaro A, Fioravanti M, Lucarelli F, Thorel M, Parmegiani M, Agnoli A (1988) Tetrahydrofolic acid and S-adenosyl methionine in the treatment of pathological aging brain and dementia. In: Agnoli A, Cohn J, Lassen N, Mayreux L (eds) Senile dementia. II. International Symposium, John Libbey Eurotext, Paris, pp 437–443

    Google Scholar 

  • Friedel HA, Goa KL, Benfield P (1989) S-Adenosyl-L-Methionie. A Review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 38: 389–416

    Article  PubMed  CAS  Google Scholar 

  • Janicak PG, Lipinski J, Davis JM, Altman E, Sharma P (1989) Parenteral S-adenosyl-methionine (SAMe) in depression: Literature review and preliminary data. Psychopharmacol Bull 25: 238–242

    PubMed  CAS  Google Scholar 

  • Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH (1990) Oral S-Adenosylmethionine in Depression: A randomized, double-blind, placebo-controlled trial. Am J Psychiatry 147: 591–595

    PubMed  CAS  Google Scholar 

  • Müller WE, Gelbmann CM, Cohen SA, Stoll L, Schubert T, Hartmann H (1992) Age-associated changes of muscarinic cholinergic and N-methyl-D-aspartate receptors in the mouse brain. Partial reconstitution by phosphatidylserine treatment. In: Balduini C, Zwilling R (eds) Biology of aging, Springer, Berlin Heidelberg New York Tokyo (in press)

    Google Scholar 

  • Rosenbaum JF, Fava M, Falk WE, Pollack MH, Cohen LS, Cohen BM, Zubenko GS (1990) The antidepressant potential of oral S-adenosyl-1-methionine. Acta Psychiatr Scand 81: 432–436

    Article  PubMed  CAS  Google Scholar 

  • Vahora SA, Malek-Ahmadi P (1988) S-Adenosylmethionine in the treatment of depression. Neu-rosci Biobehav Rev 12: 139–141

    Article  CAS  Google Scholar 

  • Valzelli L, Kozak W, Zanotti A, Toffano G (1987) Activity of phosphatidylserine on memory retrieval and on exploration in mice. Meth Find Expl Clin Pharmacol 9: 657–660

    CAS  Google Scholar 

  • Zanotti A, Valzelli L, Toffano G (1989) Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology 99: 316–321

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. W. E. Müller
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Editors and Affiliations

  1. Psychiatrische Klinik und Poliklinik, Freien Universität Berlin, Eschenallee 3, D-1000, Berlin 19, Deutschland

    Wolfgang Gaebel (Oberarzt) (Oberarzt)

  2. Psychiatrische Klinik der Universität, Füchsleinstraße 15, D-8700, Würzburg, Deutschland

    Gerd Laux (Oberarzt) (Oberarzt)

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© 1992 Springer-Verlag Berlin Heidelberg

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Müller, W.E. (1992). Neuronale Membran-Angriffsmechanismen am Beispiel von Phosphatidylserin und S-Adenosyl-Methionin. In: Gaebel, W., Laux, G. (eds) Biologische Psychiatrie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77086-9_41

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  • DOI: https://doi.org/10.1007/978-3-642-77086-9_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54784-6

  • Online ISBN: 978-3-642-77086-9

  • eBook Packages: Springer Book Archive

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