Abstract
The term “smouldering leukaemia” (SML) was first described in 1963 by Rheingold et al. [16]. They reported a variant of an acute myelogenous leukaemia (AML) for which a long survival time (8 months-3 years) without intensive therapy was found to be characteristic. Up to now there has been no clear distinction between myelodysplastic syndromes (MDS) and SML. In the literature the following expressions have been used to define SML: preleukaemia [5,7,14,15,17,23], oligoblastic leukaemia [1,18], subacute myelogenous leukaemia [9,24], chronic myelomonocytic leukaemia [24], chronic erythromonocytic leukaemia [4], hypocellular acute leukaemia [10] and MDS (dysmyelopoietic syndromes) [5, 7, 12].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Barlogie B, Johnston DA, Keating M, Spitzer G, Hittelman WN, Nishioki K, Freireich EJ (1984) Evolution of oligoleukemia. Cancer 53:2115–2124
Bennett JM, Catovsky D, Flandrin G, Galton D, Gralnick H, Sultan C (1982) The French-American-British Co-operative Group. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51:189–199
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (FAB Co-operative Group) (1976) Proposals for the classification of the acute leukaemias. Br J Haematol 33:451–458
Broun GO (1969) Chronic erythromonocytic leukemia. Am J Med 47:785–796
Dreyfus B (1976) Preleukemic states. Blood Cells 2:33–55
Fleischer W, Pelka R (1978) A practical analysis of DNA-histograms with a laboratory computer. Lutz D (ed) Pulse-Cytophotometry III. European Press, Ghent, p 137
Geary CG (1983) Clinical annotation. The diagnosis of preleukaemia. Br J Haematol 55:1–6
Greenberg PL (1983) The smouldering myeloid leukemic states: clinical and biologic features. Blood 61:1035–1044
Heimpel H, Drings P, Mitrou P, Queißer W (1979) Verlauf und prognostische Kriterien bei Patienten mit “Präleukämie”. Klin Wochenschr 57:21–29
Howe RB, Bloomfield CD, McKenna RW (1982) Hypocellular acute leukemia. Am J Med 72:391–395
Jehn U, Knüppel W, Wilmanns W (1988) Intensive maintenance treatment in acute myelogenous leukemia (AML): single institution experience of a multicenter randomized trial. Onkologie 11:13–17
Joseph AS, Cinkotal KI, Hunt L, Geary CG (1982) Natural history of smouldering leukaemia. Br J Cancer 46:160–166
Knospe WH, Gregory SA (1971) Smouldering acute leukemia. Arch Intern Med 127:910–918
Koeffler HP, Golde DW (1980) Human preleukemia. Ann Intern Med 93:347–353
Linman JW, Bagby GC (1978) The preleukemic syndrome (Hemopoietic dysplasia). Cancer 42:854–864
Rheingold JJ, Kaufman R, Adelson E, Lear A (1963) Smouldering acute leukemia. N Engl J Med 268:812–815
Saarni MI, Linman JW (1973) Preleukemia; the hematologic syndrome preceding acute leukemia. Am J Med 55:38–48
Sanchez-Fayos J, Outeriño J, Calabuig T, Perez-saldaña R, Lite M, Figuera A, Perez-rus G (1984) Biological significance of nonlymphocytic oligoblastic leukemia. Acta Haematol 72:105–110
Sauer H, Wilmanns W (1977) Cobalmin dependent methionine synthesis and methyl-folate-trap in human vitamin B12 deficiency. Br J Haematol 36:189–198
Sauer H, Wilmanns W (1982) Thymidine kinase. ATP: thymidine 5′-phosphotransferase, EC 2.7.1.21. Bergmeyer HU (ed) Methods of enzymatic analysis III. Verlag Chemie, Weinheim, p 468
Sauer H, Wilmanns W, Pelka-Fleischer R, Twardzik L, Vehling-Kaiser U, Jehn U (1987) DNA-metabolism in human bone marrow cells. Z antimikrob antineoplast Chemother 5:71–77
Slyck EJ Van, Rebuck JW, Waddell CC, Janakiraman N (1983) Smouldering acute granulocytic leukemia. Arch Intern Med 143:37–40
Weber RFA, Geraedts JPM, Kerkhofs H, Leeksma CHW (1980) The preleukemic syndrome; I. Clinical and hematological findings. Acta Med Scand 207:391–395
Zittoun R (1976) Annotation. Subacute and chronic myelomonocytic leukaemia: a distinct haematological entity. Br J Haematol 32:1–7
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Nüssler, V., Sauer, H., Pelka-Fleischer, R., Hölzel, D., Wilmanns, W. (1993). Clinical, Biochemical and Cytokinetic Parameters for Distinguishing Smouldering and Rapidly Proliferating Variants of Acute Leukemia. In: Fleischer, J. (eds) Leukemias. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77083-8_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-77083-8_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77085-2
Online ISBN: 978-3-642-77083-8
eBook Packages: Springer Book Archive