Morphology of Megakaryocytes in Chronic Myeloproliferative Diseases
Chronic myeloproliferative diseases are often characterized by proliferation of more than one cell line, which indicates involvement of the pluripotent noncommitted cell in the origin of the disorders. Megakaryocyte proliferation is often remarkable and has been repeatedly described in diseases such as polycythaemia vera, in many cases of chronic myelosis and in myelodysplastic syndromes [1–3]. The proliferating megakaryocytes are often dysplastic especially in cases of so-called granulocytic-megakaryocytic leukaemia . In histological sections, megakaryocytes show increased pleiomorphism with an increase of small, large and senescent megakaryocytes. The usual features of megakaryocyte dysplasia are the presence of large hypolobated nuclei with pale chromatin and prominent nucleoli. The number of megakaryocytic mitoses is increased. Electron microscopy reveals, in addition to the immature appearance of nuclei, abnormalities in the cytoplasm, especially focal absence of the canalicular demarcation system and an uneven distribution of the platelet granules.
KeywordsLymphoma Leukemia Paraffin Polycythemia Myelofibrosis
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