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Chemotherapy for Adult Acute Myeloid Leukemia: Study Results from the Acute Myeloid Leukemia Cooperative Group and Overview

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Leukemias

Abstract

In 1978 the Acute Myeloid Leukemia Cooperative Group (AMLCG) started its work. We take this opportunity to summarize the major results of the 10 years’ work of this study group and combine it with an overview of results from other multicenter study results as published during the past decade. What are the lessons learned from clinical study data during the 1980s resulting from more than 5000 patients treated for AML?

Supported by grants 01 ZP 012/3 and 01 ZP 8701/9 from Ministery for Research and Technology of the FRG.

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References

  1. Rai KR, Holland JF, Glidewell OJ, et al. (1981) Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B. Blood 58: 1203

    PubMed  CAS  Google Scholar 

  2. Yates J, Glidewell O, Wiernik P, et al. (1982) Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB Study. Blood 60: 454

    PubMed  CAS  Google Scholar 

  3. Sauter C, Fopp M, Imbach P, et al. (1984) Acute myelogenous leukemia: maintenance chemotherapy after early consolidation treatment does not prolong survival. Lancet 1: 379

    Article  PubMed  CAS  Google Scholar 

  4. Vogler WR, Winton EF, Gordon DS, et al. (1984) A randomized comparison of postremission therapy in acute myelogenous leukemia: a southeastern cancer study group trial. Blood 63: 1039

    PubMed  CAS  Google Scholar 

  5. Cassileth PA, Begg CB, Bennett JM, et al. (1984) A randomized study of the efficacy of consolidation therapy in adult acute nonlymphocytic leukemia. Blood 63: 843

    PubMed  CAS  Google Scholar 

  6. Hayat M, Jehn U, Willemze R, et al. (1986) A randomized comparison of maintenance treatment with androgens, immunotherapy, and chemotherapy in adult acute myelogenous leukemia. A leukemia-lymphoma group trial of the EORTC. Cancer 58: 617

    Article  PubMed  CAS  Google Scholar 

  7. Rees JKH, Swirsky D, Gray RG, Hayhoe FGJ (1986) Principal results of the medical research council’s 8th acute myeloid leukemia trial. Lancet 11: 1236

    Article  Google Scholar 

  8. Preisler H, Davis RB, Kirshner J, et al. (1987) Comparison of three remission induction regimens and two postinduction strategies for the treatment of acute nonlymphocytic leukemia: a cancer and leukemia group B study. Blood 69: 1441

    PubMed  CAS  Google Scholar 

  9. Cassileth PA, Harrington DP, Hines JD, et al. (1988) Maintenance chemotherapy prolongs remission duration in adult acute nonlymphocytic leukemia. J Clin Oncol 6: 538

    Google Scholar 

  10. Büchner T, Urbanitz D, Hiddemann W, et al. (1985) Intensified induction and consolidation with or without maintenance chemotherapy for acute myeloid leukemia (AML): two multicenter studies of the German AML cooperative group. J Clin Oncol 3: 1583

    PubMed  Google Scholar 

  11. Büchner T, Hiddemann W, Koch P, et al. (1988) The role of myelosuppressive maintenance, immunotherapy, induction dose reduction in higher age, and double induction in adult acute myeloid leukemia (AML). Four studies of the AML cooperative group. In: Kimura K, et al. (eds) Cancer Chemotherapy: Challenges for the furture. Excerpta Medica, Tokyo, p 119

    Google Scholar 

  12. Büchner T, Urbanitz D, Rühl H, et al. (1985) Role of chemotherapy for AML in remission. Lancet 1: 1224

    Article  PubMed  Google Scholar 

  13. Büchner T, Hiddemann W, Wendt F, et al. (1987) Early intensification by double induction (DI) in adult AML: a multicenter study of the AML cooperative group. Blood 70 [Suppl 1]: 752

    Google Scholar 

  14. Hiddemann W, Kreutzmann H, Straif K, et al. (1987) High-dose cytosine arabinoside and mitoxantrone (HAM): a highly effective regimen in refractory acute myeloid leukemia. Blood 69: 744

    PubMed  CAS  Google Scholar 

  15. Büchner T, Hiddemann W, Koenigsmann M, et al. (1988) Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) for acute leukemias in aplasia and at high risk of early death. Blood 72 [Suppl 1]: 354

    Google Scholar 

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© 1993 Springer-Verlag Berlin Heidelberg

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Büchner, T. et al. (1993). Chemotherapy for Adult Acute Myeloid Leukemia: Study Results from the Acute Myeloid Leukemia Cooperative Group and Overview. In: Fleischer, J. (eds) Leukemias. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77083-8_41

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  • DOI: https://doi.org/10.1007/978-3-642-77083-8_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77085-2

  • Online ISBN: 978-3-642-77083-8

  • eBook Packages: Springer Book Archive

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