Abstract
The description of a decrease in the intracellular accumulation of a number of cytostatics, such as anthracyclines, vinca alkaloids, epipodophyllotoxins, and actinomycin D, in drug-resistant malignant cells, which was first demonstrated for colchicine in Chinese hamster ovary cells [4], has substantially contributed to the understanding of “multidrug resistance” [6]. This process is caused by an energy-dependent outward pump in connection with the expression of the 170000-Da plasma membrane glycoprotein P170 [21].
Supported by Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, Sonderforschungsbereich 102.
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© 1993 Springer-Verlag Berlin Heidelberg
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Scheulen, M.E., Kramer, B., Skorzec, M., Reich, W.K. (1993). Cellular Pharmacokinetics of Daunomycin in Human Leukemic Blasts In Vitro and In Vivo. In: Fleischer, J. (eds) Leukemias. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77083-8_39
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DOI: https://doi.org/10.1007/978-3-642-77083-8_39
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