Leukemias pp 167-171 | Cite as

Interferon-α and Hairy Cell Leukemia

  • J. D. Schwarzmeier
  • G. C. Ihra
Conference paper

Abstract

The excellent therapeutic response of hairy cell leukemia (HCL) to natural interferon-a (IFN-α) reported for the first time by Quesada et al. [1] and subsequently confirmed by numerous studies using recombinant IFN-α (e.g. [2]), has prompted a broad array of clinical trials with this substance. Among the diseases investigated so far, HCL is still the most sensitive disorder and has become a model system for the investigation of the antitumor effects of IFN-α.

Keywords

Depression Leukemia Anemia Diarrhea Interferon 

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References

  1. 1.
    Quesada JR, Reuben J, Manning JT, Hersh EM, Gutterman JU (1984) Alpha interferon for induction of remission in hairy cell leukemia. N Engl J Med 310:15PubMedCrossRefGoogle Scholar
  2. 2.
    Hofmann V, Scheel A, Schwarzmeier J, et al. (1985) Wirksamkeit von Interferon-α2 bei der Haarzeil Leukämie. Schweiz Med Wochenschrift 115:235Google Scholar
  3. 3.
    Schwarzmeier JD, Schwabe M, Prischl F, Wagner L, Lion T, Micksche M, Köller U (1987) Interferon-alpha-2 for hairy cell leukemia: Evidence for induction of RNA synthesis in hairy cells and failure to corríate enhancement of natural killer cells with elimination of hairy cells. Eur J Haematol 39:418PubMedCrossRefGoogle Scholar
  4. 4.
    Griffiths SD, Cawley JC (1990) The effect of cytokines, including IL-1, IL-4, and IL-6, in hairy cell proliferation/differentiation. Leukemia 4:337PubMedGoogle Scholar
  5. 5.
    Michalewiz R, Revel M (1987) Interferons regulate the in vitro differentiation of multilineage lymphomyeloid stem cells in hairy cell leukemia. Proc Natl Acad Sci USA 84:2307CrossRefGoogle Scholar
  6. 6.
    Taniguchi N, Karatsune H, Kanamaru A, Tokumine Y, Tagawa S, Machii T, Kitani T (1989) Inhibition against CFU-C and CFU-E colony formation by soluble factors derived from hairy cells. Blood 73:907PubMedGoogle Scholar
  7. 7.
    Gasché C, Reinisch W, Winkler K, Schwarzmeier JD (1992) Myelosuppression in hairy cell leukemia: role of hairy cells, haemopoietic growth factors, and tumor necrosis factor-a/ß. (submitted)Google Scholar
  8. 8.
    Glaspy JA, Baldwin GC, Robertson PA, Souza L, Vincent M, Ambersley J, Golde DW (1988) Therapy for neutropenia in hairy cell leukemia with recombinant human granulocyte colony-stimulating factor. Ann Int Med 109:789PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. D. Schwarzmeier
    • 1
  • G. C. Ihra
  1. 1.1st Medical University Clinic, AKH-WienViennaAustria

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