The excellent therapeutic response of hairy cell leukemia (HCL) to natural interferon-a (IFN-α) reported for the first time by Quesada et al.  and subsequently confirmed by numerous studies using recombinant IFN-α (e.g. ), has prompted a broad array of clinical trials with this substance. Among the diseases investigated so far, HCL is still the most sensitive disorder and has become a model system for the investigation of the antitumor effects of IFN-α.
KeywordsNatural Killer Cell Colony Formation Hairy Cell Leukemia Hairy Cell Minor Response
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- 2.Hofmann V, Scheel A, Schwarzmeier J, et al. (1985) Wirksamkeit von Interferon-α2 bei der Haarzeil Leukämie. Schweiz Med Wochenschrift 115:235Google Scholar
- 3.Schwarzmeier JD, Schwabe M, Prischl F, Wagner L, Lion T, Micksche M, Köller U (1987) Interferon-alpha-2 for hairy cell leukemia: Evidence for induction of RNA synthesis in hairy cells and failure to corríate enhancement of natural killer cells with elimination of hairy cells. Eur J Haematol 39:418PubMedCrossRefGoogle Scholar
- 7.Gasché C, Reinisch W, Winkler K, Schwarzmeier JD (1992) Myelosuppression in hairy cell leukemia: role of hairy cells, haemopoietic growth factors, and tumor necrosis factor-a/ß. (submitted)Google Scholar