The excellent therapeutic response of hairy cell leukemia (HCL) to natural interferon-a (IFN-α) reported for the first time by Quesada et al.  and subsequently confirmed by numerous studies using recombinant IFN-α (e.g. ), has prompted a broad array of clinical trials with this substance. Among the diseases investigated so far, HCL is still the most sensitive disorder and has become a model system for the investigation of the antitumor effects of IFN-α.
KeywordsDepression Leukemia Anemia Diarrhea Interferon
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