Leukemias pp 117-121 | Cite as

Enhancement of Growth of Murine Colony-Forming Units-Granulocyte-Macrophage at Suboptimal Colony-Stimulating Factor-Granulocyte-Macrophage Concentrations by Nucleosides, Nucleobases and Their Analogues, and the Dimer of the Hemoregulatory Pentapeptide

  • P. Langen
  • H. Schunck
  • B. Hunger
  • M. Schütt
  • O. D. Laerum
Conference paper


As reported earlier, deoxycytidine (dC) antagonizes the effect of a natural growth inhibitor, isolated from bovine mammary gland, on mouse Ehrlich ascites carcinoma cells in the same way as the polypeptide growth factors insulin and epidermal growth-factor (EGF) do [6]. Bhalla et al. [1] found that this nucleoside is able to overcome the inhibitory effect of acidic isoferritin, prostaglandin E1 and leukemia inhibitory factor on colony-forming unit-granulocyte macrophage (CFU-GM). Moreover, these authors found that dC stimulates the growth of CFU-GM. We demonstrated [8] that dC antagonizes the effect of the hemoregulatory pentapeptide, described by Kreja et al. [3], and of an inhibitor of colony-forming unit-spleen (CFU-S), described by Lord et al. [7]. Again, dC effects were identical to those of insulin and EGF in these systems.


Leukemia Inhibitory Factor Bovine Mammary Gland Normal Bone Marrow Cell Acta Pathol Microbiol Immunol High Receptor Occupancy 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. Langen
    • 1
  • H. Schunck
  • B. Hunger
  • M. Schütt
  • O. D. Laerum
  1. 1.Central Institute of Molecular BiologyAcademy of SciencesBerlinGermany

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