Enhancement of Growth of Murine Colony-Forming Units-Granulocyte-Macrophage at Suboptimal Colony-Stimulating Factor-Granulocyte-Macrophage Concentrations by Nucleosides, Nucleobases and Their Analogues, and the Dimer of the Hemoregulatory Pentapeptide
As reported earlier, deoxycytidine (dC) antagonizes the effect of a natural growth inhibitor, isolated from bovine mammary gland, on mouse Ehrlich ascites carcinoma cells in the same way as the polypeptide growth factors insulin and epidermal growth-factor (EGF) do . Bhalla et al.  found that this nucleoside is able to overcome the inhibitory effect of acidic isoferritin, prostaglandin E1 and leukemia inhibitory factor on colony-forming unit-granulocyte macrophage (CFU-GM). Moreover, these authors found that dC stimulates the growth of CFU-GM. We demonstrated  that dC antagonizes the effect of the hemoregulatory pentapeptide, described by Kreja et al. , and of an inhibitor of colony-forming unit-spleen (CFU-S), described by Lord et al. . Again, dC effects were identical to those of insulin and EGF in these systems.
KeywordsLeukemia Inhibitory Factor Bovine Mammary Gland Normal Bone Marrow Cell Acta Pathol Microbiol Immunol High Receptor Occupancy
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