Megakaryocytopoiesis in Patients with Myelodysplastic Syndromes

  • M. Podolak-Dawidziak
  • D. Geddesa
  • D. Bowen
Conference paper


Myelodysplastic syndrome (MDS) is a progressive preleukaemic condition caused by an abnormality of haemopoietic stem cells [1,10] and characterized by both genetic and functional changes [3,4]. Dysmegakaryocyto-poiesis is a common feature in MDS and results in thrombocytopenia in about 50% of cases [4]. Megakaryocyte colony formation was found to be defective in many MDS patients [5,6]. Futhermore, MDS plasma displayed a low ability to support the clonal growth of normal megakaryocytopoietic progenitors [13]. Although the number of marrow megakaryocytes may be decreased, normal or increased, they are often morphologically abnormal with reduced size (micromegakaryocytes) [2,14,19] and small hypo- or nonlobulated nuclei [13,16]. The degree of dysmegakaryocytopoiesis along with the degree of dysgranulocytopoiesis has been introduced as an additional criterion aiming at better prediction of patients’ survival than that based on the French-American-British Group (FAB) classification alone [1,18].


Acute Myeloid Leukemia Myelodysplastic Syndrome Normal Bone Marrow Refractory Anaemia Sideroblastic Anaemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. Podolak-Dawidziak
    • 1
  • D. Geddesa
  • D. Bowen
  1. 1.Department of HaematologyMedical AcademyWrocławPoland

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