Abstract
Myelodysplastic syndrome (MDS) is a progressive preleukaemic condition caused by an abnormality of haemopoietic stem cells [1,10] and characterized by both genetic and functional changes [3,4]. Dysmegakaryocyto-poiesis is a common feature in MDS and results in thrombocytopenia in about 50% of cases [4]. Megakaryocyte colony formation was found to be defective in many MDS patients [5,6]. Futhermore, MDS plasma displayed a low ability to support the clonal growth of normal megakaryocytopoietic progenitors [13]. Although the number of marrow megakaryocytes may be decreased, normal or increased, they are often morphologically abnormal with reduced size (micromegakaryocytes) [2,14,19] and small hypo- or nonlobulated nuclei [13,16]. The degree of dysmegakaryocytopoiesis along with the degree of dysgranulocytopoiesis has been introduced as an additional criterion aiming at better prediction of patients’ survival than that based on the French-American-British Group (FAB) classification alone [1,18].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C, The French-American-British (FAB) Co-operative group (1982) Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51:189–199
Bracher C (1974) Atypical megakaryocytes. A reflection of a stem cell disorder. In: Baldini M, Ebbe S (eds) Platelets: production, function, transfusion and storage. Grune and Stratton, New York, pp 94–103
Greenberg PL (1983) The smouldering myeloid leukemic status: clinical and biologic feature. Blood 61:1035–1044
Jacobs A (1985) Myelodysplastic syndrome: pathogenesis, functional abnormalities, and clinical implications. J Clin Pathol 38:1201–1217
Juvonen E, Partanen E, Knuutila S, Ruutu T (1986) Megakaryocyte colony formation by bone marrow progenitors in myelodysplastic syndromes. Br J Haematol 63:331–334
Juvonen E, Partanen E, Knuutila S, Ruutu T (1989) Colony formation by megakaryocyte progenitors in myelodysplastic syndromes. Eur J Haematol 42:389–395
LeBeau MM, Epstein MD, O’Brien SJ, Nienhuis AW, Yang Y, Clark SC, Rowley JD (1987) The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. Proc Natl Acad Sci USA 84:5913–5917
LeBeau MM, Westbrook CA, Diaz MO, Larson RA, Rowley JD, Gasson JC, Golde DW, Sherr CJ (1986) Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders. Science 251:984–987
Levine RF (1980) Isolation and characterization of normal human megakaryocytes. Br J Haematol 45:487–497
Linman JW, Saarni MJ (1974) The preleukemic syndrome. Semin Hematol 11:93–100
Messner HA, Jamal N, Izaguirre C (1982) The growth of large megakaryocyte colonies from human bone marrow. J Cell Physiol 1:45–51
Paris Conference (1971) Standarization in human cytogenetics. Birth Defects 8:1972
Podolak-Dawidziak M (1989) Stimulation of CFU-Mk colony growth by normal plasma and plasma from myelodysplastic patients. Leuk Res 13:213–215
Smith WB, Ablin A, Goodman JR, Brecher G (1973) Atypical megakaryocytes in preleukemic phase of acute myeloid leukemia. Blood 42:535–540
Sokal G, Michaux JL, van den Berghe H, Cordier A, Rodhain J, Ferrant A, Mariau M, De Bruyere M, Sonnet J (1975) A new hematologic syndrome with a distinct karyotype: the 5q-chromosome. Blood 46:519–533
Tricot G, Vlietinck R, Boogaerts MA, Hendriks B, De Wolf-Peters C, van den Berghe H, Verwilgen RL (1985) Prognostic factors in the myelodysplastic syndromes: importance of initial data on peripheral blood counts, bone marrow cytology, trophine biopsy and chromosomal analysis. Br J Haematol 60:19–32
van den Berghe H, Cassiman JJ, David G, Fryns JP, Michaux JL, Sokal G (1974) Distinct haematological disorder with deletion of long arm of no 5 chromosome. Nature 251:437–438
Varela BL, Chuang C, Woll JE, Bennett JM (1985) Modification in the classification of primary myelodysplastic syndromes: the addition of a scoring system. Hematol Oncol 3:55–63
Wiesneth M, Pflieger H, Kubanek B, Heimpel H (1980) Micromegakaryocytes in human bone marrow. Acta Haematol 64:65–71
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Podolak-Dawidziak, M., Geddesa, D., Bowen, D. (1993). Megakaryocytopoiesis in Patients with Myelodysplastic Syndromes. In: Fleischer, J. (eds) Leukemias. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77083-8_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-77083-8_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77085-2
Online ISBN: 978-3-642-77083-8
eBook Packages: Springer Book Archive