Chemotherapy and Erythropoietin Production

  • C. Pohl
  • A. Moter
  • D. Hasenclever
  • E. M. Woll
  • M. Löffler
  • C. A. Baldamus
Conference paper


Erythropoietin (Epo) is a glycoprotein growth factor which controls erythropoiesis in mammals. It is well established that renal Epo production is stimulated solely by anemia and low arterial oxygen tension. While the Epo-deficient anemia of chronic renal insufficiency can now be treated effectively with recombinant human Epo [15], the usefulness of Epo therapy for hyporegenerative nonrenal anemia of malignant or chronic inflammatory disease is still under discussion [1, 5, 10-13, 18]. With regard to these conflicting data more information on Epo levels during chemotherapy is required. In the present study the correlation between the degree of chemotherapy-induced anemia and Epo levels was examined systematically in 24 patients with gastrointestinal neoplasia, high-grade non-Hodgkin’s lymphoma or testicular cancer.


Testicular Cancer Bone Marrow Function Proc ASCO Erythropoietin Production Acute Blood Loss 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • C. Pohl
  • A. Moter
  • D. Hasenclever
  • E. M. Woll
  • M. Löffler
  • C. A. Baldamus

There are no affiliations available

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