Abstract
The most mature erythroid progenitor cells — colony forming units – erythroid (CFU-E) — give rise to the smallest colonies in the semisolid culture system of methylcellulose, plasma clots, or agar. More primitive cells — burst forming units-erythroid (BFU-E) — give rise to progressively larger colonies (called bursts) that hemoglobinize at correspondingly later times than CFU-E [6, 9]. The development of these colonies from normal bone marrow and peripheral blood requires the addition of erythropoietin (Epo) to the cultures. Erythroid colonies derived from bone marrow and peripheral blood cells of patients with polycythemia vera (PV) and some patients with idiopathic myelofibrosis (MF) or chronic granulocyte leukemia (CGL) can develop in semisolid culture medium also without the addition of Epo [1,3,8].
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References
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© 1992 Springer-Verlag Berlin Heidelberg
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Robak, T. (1992). Antigenic Characteristics of Erythropoietin-Dependent and -Independent Erythroid Progenitors in Chronic Myeloproliferative Disorders Defined by Monoclonal Antibodies. In: Pagel, H., Weiss, C., Jelkmann, W. (eds) Pathophysiology and Pharmacology of Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77074-6_29
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DOI: https://doi.org/10.1007/978-3-642-77074-6_29
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