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Cardiological Findings in Patients with End-Stage Renal Failure Under Treatment with Erythropoietin

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Pathophysiology and Pharmacology of Erythropoietin

Abstract

The extent of left ventricular myocardial hypertrophy is generally considered to be a predictor of cardiac morbidity and mortality (Devereux et al. 1984; Levy et al. 1988, 1990). The evolution of left ventricular hypertrophy has been causally related to coronary artery disease (CAD), arterial hypertension, and increased cardiac output (Devereux 1990; Messerli and Schmieder 1990; Koren et al. 1991). This is apparently also the case with patients with end-stage renal disease undergoing chronic intermittent hemodialysis treatment (Bullock et al. 1984; Kramer et al. 1986a,b; Harnett et al. 1988; Silberberg et al. 1989).Whether secondary hyperparathyroidism significantly contributes to myocardial fibrosis in patients on hemo- or peritoneal dialysis does, however, appear doubtful at the present time (London et al. 1987a,b; Mall et al. 1990; Hüting et al. 1991a,b).

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© 1992 Springer-Verlag Berlin Heidelberg

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Schütterle, G., Kramer, W., Schäfer, R., Kaufmann, J., Wizemann, V. (1992). Cardiological Findings in Patients with End-Stage Renal Failure Under Treatment with Erythropoietin. In: Pagel, H., Weiss, C., Jelkmann, W. (eds) Pathophysiology and Pharmacology of Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77074-6_20

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  • DOI: https://doi.org/10.1007/978-3-642-77074-6_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77076-0

  • Online ISBN: 978-3-642-77074-6

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