Effects of Exercise on Plasma Erythropoietin in Natives Living Permanently at High Altitude

  • W. Schmidt
  • H. Spielvogel
  • K. U. Eckardt
  • A. Quintela
  • R. Penaloza
Conference paper


The effects of inspiratory hypoxia on the erythropoietin (EPO) system decisively depend on the duration of the exposure to the hypoxic environment. Whereas a stay of some hours in a hypobaric chamber leads to markedly increased serum [EPO] (Eckardt et al. 1989), it could be demonstrated by Milledge and Cotes (1985) that members of a Himalaya expedition had, after a rapid increase in EPO values, presented decreasing EPO values during the second half of their altitude exposure. Furthermore, Winslow et al. (1989) showed low EPO concentrations in the blood of high-altitude natives from Nepal and Chile, which are similar to those of subjects living at sea level. The reasons for the adaptation of the EPO response to chronic hypoxia are not completely understood. It may only in part be attributed to other adaptive processes, e.g., increased hemoglobin concentration [Hb] or lower pH values.


Maximal Exercise Submaximal Exercise Chronic Hypoxia Reticulocyte Count Brilliant Cresyl Blue 
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  1. Berglund B, Birgegard G, Hemmingsson P (1988) Serum erythropoietin in cross country skiers. Med Sci Sports Exerc 20: 208–209PubMedCrossRefGoogle Scholar
  2. Eckardt KU, Kurtz A, Hirth P, Scigalla P, Wieczorek L, Bauer C (1988) Evaluation of the stability of human erythropoietin in samples for radioimmunoassay. Klin Wochenschr 66: 241–245PubMedCrossRefGoogle Scholar
  3. Eckardt KU, Bouttellier U, Kurtz A, Schopen M, Koller EA, Bauer C (1989) Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J Appl Physiol 66: 1785–1788PubMedGoogle Scholar
  4. Eckardt KU, Kurtz A, Bauer C (1990) Triggering of erythropoietin production by hypoxia is inhibited by respiratory and metabolic acidosis. Am J Physiol 258: R678–R683PubMedGoogle Scholar
  5. Galbo J (1983) Hormonal and metabolic adaptation to exercise. Thieme, StuttgartGoogle Scholar
  6. Kurtz A, Eckardt KU, Tannahill L, Bauer C (1988) Regulation of erythropoietin production. Contrib Nephrol 66: 1–16PubMedGoogle Scholar
  7. Milledge JS, Cotes PM (1985) Serum erythropoietin in humans at high altitude and its relation to plasma renin. J Appl Physiol 59: 360–364PubMedGoogle Scholar
  8. Monge MC (1925) Sobre un caso de enfermedad de Vaquez. Communicacion presentada a la Academia Nacional de Medicina, Lima, pp. 1–6Google Scholar
  9. Pagel H, Jelkmann W,Weiss C (1988) A comparison of the effects of renal artery constriction and anemia on the production of erythropoietin. Pflugers Arch 413: 62–66Google Scholar
  10. Pagel H, Jelkmann W, Weiss C (1989) 02 Supply to the kidneys and the production of erythropoietin. Respir Physiol 77:111–117PubMedCrossRefGoogle Scholar
  11. Poortmans JR (1984) Exercise and renal function. Sports Med 1: 125–153PubMedCrossRefGoogle Scholar
  12. Schmidt W, Brabant G, Kroger C, Hilgendorf A, Strauch S (1990a) Atrial natriuretic peptide during and after maximal and submaximal exercise under normoxic and hypoxic conditions. Eur J Appl Physiol 61: 398–407CrossRefGoogle Scholar
  13. Schmidt W, Maassen N, Heuer D, Heck J, Boning D (1990b) Regulation of plasma volume and erythropoiesis during a ten day lasting cycling race. In: Hermans GPH, Mosterd WL (eds) Sports, medicine and health. Elsevier, Amsterdam, pp 505–512Google Scholar
  14. Schmidt W, Eckardt KU, Hilgendorf A, Strauch S, Bauer C (1991) Effects of maximal and submaximal exercise under normoxic and hypoxic conditions on serum erythropoietin level. Int J Sports Med 12: 457–461PubMedCrossRefGoogle Scholar
  15. Vedovato M, De Paoli Vitali E, Guglielmini C, Casoni I, Ricci G, Masotti M (1988) Erythropoietin in athletes of endurance events. Nephron 48: 78–79PubMedCrossRefGoogle Scholar
  16. Winslow RM, Chapman KW, Gibson C, Samaja M, Monge CC, Goldwasser E, Sherpa M, Blume FD, Santolaya R (1989) Different hematologic responses to hypoxia in Sherpas and Quechua Indians. J Appl Physiol 66: 1561–1569PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • W. Schmidt
  • H. Spielvogel
  • K. U. Eckardt
  • A. Quintela
  • R. Penaloza

There are no affiliations available

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