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Steroidglaukom

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Glaukom

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Zusammenfassung

Wie bereits in Kap. 9 besprochen, wird ein bestimmter Prozentsatz der allgemeinen Bevölkerung auf eine wiederholte lokale wie auch systemische Steroidmedikation mit unterschiedlichem Augeninnendruckanstieg reagieren. Dies tritt bei Patienten mit einem primären Offenwinkelglaukom oder einer Familienanamnese von Glaukom häufiger auf. Es gibt noch viele ungeklärte Aspekte bezüglich des Effektes von Steroiden auf den Augeninnendruck, wie z. B. die genaue Verteilung von Steroid-“Respondern“in der allgemeinen Bevölkerung, die Reproduzierbarkeit der Steroideffekte auf den Augeninnendruck oder die hereditären Einflüsse. Dies ändert nichts an der kritischen Tatsache, daß bestimmte Menschen auf eine längerfristige Steroidtherapie mit massiven Augen-drucksteigerungen reagieren und, daß diese Drucksteigerungen zu einer glaukomatosen Optikusatrophie und zum Verlust des Sehvermögens führen können. Eine derartige Situation wird deshalb als Steroidglaukom bezeichnet.

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Literatur

  1. McLean, JM: Use of ACTH and cortisone. Discussion of paper of Woods, AC. Trans Am Ophthal Soc 48:293, 1950.

    Google Scholar 

  2. Francois, J: Cortisone et tension oculaire. Ann D’Oculist 187:805, 1954.

    CAS  Google Scholar 

  3. Francois, J: Corticosteroid glaucoma. Ann Ophthal 9:1075, 1977.

    PubMed  CAS  Google Scholar 

  4. Weinreb, RN, Polansky, JR, Kramer, SG, Baxter, JD: Acute effects of dexamethasone on intraocular pressure in glaucoma. Invest Ophthal Vis Sci 26:170, 1985.

    PubMed  CAS  Google Scholar 

  5. Biedner, B-A, David, R, Grudsky, A, Sachs, U: Intraocular pressure response to corticosteroids in children. Br J Ophthal 64:430, 1980.

    Article  CAS  Google Scholar 

  6. Gnad, HD, Martenet, AC: Kongenitales Glaukom and Cortison. Klin Monatsbl Augenheilkd 162:86, 1973.

    PubMed  CAS  Google Scholar 

  7. Wilensky, JT, Snyder, D, Gieser, D: Steroid- induced ocular hypertension in patients with filtering blebs. Ophthalmology 87:240, 1980.

    PubMed  CAS  Google Scholar 

  8. Sugar, HS: Low tension glaucoma: a practical approach. Ann Ophthal 11:1155, 1979.

    PubMed  CAS  Google Scholar 

  9. Armaly, MF: Effect of corticosteroids on intraocular pressure and fluid dynamics. II. The effect of dexamethasone in the glaucomatous eye. Arch Ophthal 70:492, 1963.

    PubMed  CAS  Google Scholar 

  10. Miller, D, Peczon, JD, Whitworth, CG: Corticosteroids and functions in the anterior segment of the eye. Am J Ophthal 59:31, 1965.

    PubMed  CAS  Google Scholar 

  11. Kupfer, C, Ross, K: Studies of aqueous humor dynamics in man. I. Measurements in young normal subjects. Invest Ophthal 10:518, 1971.

    PubMed  CAS  Google Scholar 

  12. Tchernitchin, A, Wenk, EJ, Hernandez, MR, et al: Glucocorticoid localization by radioautography in the rabbit eye following systemic administration of 3H-dexamethasone. Invest Ophthal Vis Sci 19:1231, 1980.

    CAS  Google Scholar 

  13. Weinreb, RN, Bloom, E, Baxter, JD, et al: Detection of glucocorticoid receptors in cultured human trabecular cells. Invest Ophthal Vis Sci 21:403, 1981.

    PubMed  CAS  Google Scholar 

  14. McCarty, GR, Schwartz, B: Increased concentration of glucocorticoid receptors in rabbit iris-ciliary body compared to rabbit liver. Invest Ophthal Vis Sci 23:525, 1982.

    PubMed  CAS  Google Scholar 

  15. Southren, AL, Dominguez, MO, Gordon, GG, et al: Nuclear translocation of the cytoplasmic glucocorticoid receptor in the iris-ciliary body and adjacent corneoscleral tissue of the rabbit following topical administration of various glucocorticoids. Invest Ophthal Vis Sci 24:147, 1983.

    PubMed  CAS  Google Scholar 

  16. Southren, AL, Gordon, GG, l’Hommedieu, D, et al: 5B-Dihydrocortisol: possible mediator of the ocular hypertension in glaucoma. Invest Ophthal Vis Sci 26:393, 1985.

    PubMed  CAS  Google Scholar 

  17. Francois, J, Victoria-Troncoso, V: Mucopolysaccharides and pathogenesis of cortisone glaucoma. Klin Monatsbl Augenheilkd 165:5, 1974.

    PubMed  CAS  Google Scholar 

  18. Francois, J: The importance of the mucopolysaccharides in intraocular pressure regulation. Invest Ophthal 14:173, 1975.

    PubMed  CAS  Google Scholar 

  19. Francois, J: Tissue culture of ocular fibroblasts. Ann Ophthal 11:1551, 1975.

    Google Scholar 

  20. Hayasaka, S: Lysosomal enzymes in ocular tissues and diseases. Surv Ophthal 27:245, 1983.

    Article  CAS  Google Scholar 

  21. Spaeth, GL, Rodrigues, MM, Weinreb, S: Steroid-induced glaucoma: A. Persistent elevation of intraocular pressure. B. Histopathological aspects. Trans Am Ophthal Soc LXXV:353, 1977.

    Google Scholar 

  22. Ticho, U, Lahav, M, Berkowitz, S, Yoffe, P: Ocular changes in rabbits with corticosteroid-induced ocular hypertension. Br J Ophthal 63:646, 1979.

    Article  CAS  Google Scholar 

  23. Knepper, PA, Collins, JA, Frederick, R: Effect of dexamethasone, progesterone, and testosterone on IOP and GAGs in the rabbit eye. Invest Ophthal Vis Sci 26:1093, 1985.

    PubMed  CAS  Google Scholar 

  24. Hernandez, MR, Weinstein, BI, Dunn, MW, et al: The effect of dexamethasone on the synthesis of collagen in normal human trabecular meshwork explants. Invest Ophthal Vis Sci 26:1784, 1985.

    PubMed  CAS  Google Scholar 

  25. Bill, A: The drainage of aqueous humor. Invest Ophthal 14:1, 1975.

    PubMed  CAS  Google Scholar 

  26. Rohen, JW, Linner, E, Witmer, R: Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid-glaucoma. Exp Eye Res 17:19, 1973.

    Article  PubMed  CAS  Google Scholar 

  27. Roll, P, Benedikt, O: Electronmicroscopic investigation of the trabecular meshwork in cortisone glaucoma. Klin Monatsbl Augenheilkd 174:421, 1979.

    PubMed  CAS  Google Scholar 

  28. Schirru, A, Pecori-Giraldi, J, Pellegrino, N: Topical corticosteroids and vitreous dynamics in the rabbit. Acta Ophthal 51:811, 1973.

    Article  PubMed  CAS  Google Scholar 

  29. Virno, M, Schirru, A, Pecori-Giraldi, J, Pellegrino, N: Aqueous humor alkalosis and marked reduction in ocular ascorbic acid content following long-term topical cortisone (9a-fluoro-16a-methylprednisolone). Ann Ophthal 6:983, 1974.

    PubMed  CAS  Google Scholar 

  30. Spaeth, GL: The effect of autonomic agents on the pupil and the intraocular pressure of eyes treated with dexamethasone. Br J Ophthal 64:426, 1980.

    Article  CAS  Google Scholar 

  31. Kimura, R, Honda, M: Effect of orally administered hydrocortisone on the rate of aqueous flow in man. Acta Ophthal 60:584, 1982.

    Article  PubMed  CAS  Google Scholar 

  32. Rice, SW, Bourne, WM, Brubaker, RF: Absence of an effect of topical dexamethasone on endothelial permeability and flow of aqueous humor. Invest Ophthal Vis Sci 24:1307, 1983.

    PubMed  CAS  Google Scholar 

  33. Podos, SM, Becker, B, Morton, WR: High myopia and primary open-angle glaucoma. Am J Ophthal 62:1039, 1966.

    Google Scholar 

  34. Becker, B: Diabetes mellitus and primary open-angle glaucoma. Am J Ophthal 71:1, 1971.

    PubMed  CAS  Google Scholar 

  35. Gaston, H, Absolon, MJ, Thurtle, OA, Sattar, MA: Steroid responsiveness in connective tissue diseases. Br J Ophthal 67:487, 1983.

    Article  CAS  Google Scholar 

  36. Cubey, RB: Glaucoma following the application of corticosteroid to the skin of the eyelids. Br J Dermatol 95:207, 1976.

    Article  PubMed  CAS  Google Scholar 

  37. Zugerman, C, Sauders, D, Levit, F: Glaucoma from topically applied steroids. Arch Dermatol 112:1326, 1976.

    Article  PubMed  CAS  Google Scholar 

  38. Vie, R: Glaucoma and amaurosis associated with long-term application of topical corticosteroids to the eyelids. Acta Derm Venereol 60:541, 1980.

    PubMed  CAS  Google Scholar 

  39. Kalina, RE: Increased intraocular pressure following subconjunctival corticosteroid administration. Arch Ophthal 81:788, 1969.

    PubMed  CAS  Google Scholar 

  40. Nozik, RA: Periocular injection of steroids. Trans Am Acad Ophthal Otol 76:695, 1972.

    CAS  Google Scholar 

  41. Herschler, J: Intractable intraocular hypertension induced by repository triamcinolone acetonide. Am J Ophthal 74:501, 1972.

    PubMed  CAS  Google Scholar 

  42. Herschler, J: Increased intraocular pressure induced by repository corticosteroids. Am J Ophthal 82:90, 1976.

    PubMed  CAS  Google Scholar 

  43. Ferry, AP, Harris, WP, Nelson, MH: Histopathologic features of subconjunctivally injected corticosteroids. Am J Ophthal 103:716, 1987.

    PubMed  CAS  Google Scholar 

  44. Stern, JJ: Acute glaucoma during cortisone therapy. Am J Ophthal 36:389, 1953.

    PubMed  CAS  Google Scholar 

  45. Covell, LL: Glaucoma induced by systemic steroid therapy. Am J Ophthal 45:108, 1958.

    PubMed  CAS  Google Scholar 

  46. Godel, V, Feiler-Ofry, V, Stein, R: Systemic steroids and ocular fluid dynamics. I. Analysis of the sample as a whole. Influence of dosage and duration of therapy. Acta Ophthal 50:655, 1972.

    Article  PubMed  CAS  Google Scholar 

  47. Godel, V, Feiler-Ofry, V, Stein, R: Systemic steroids and ocular fluid dynamics. II. Systemic versus topical steroids. Acta Ophthal 50:664, 1972.

    Article  PubMed  CAS  Google Scholar 

  48. Adhikary, HP, Sells, RA, Basu, PK: Ocular complications of systemic steroid after renal transplantation and their association with HL A. Br J Ophthal 66:290, 1982.

    Article  CAS  Google Scholar 

  49. Kitazawa, Y: Increased intraocular pressure induced by corticosteroids. Am J Ophthal 82:492, 1976.

    PubMed  CAS  Google Scholar 

  50. Leibowitz, HM, Kupperman, A, Stewart, RH, Kimbrough, RL: Evaluation of dexamethasone acetate as a topical ophthalmic formulation. Am J Ophthal 86:418, 1978.

    PubMed  CAS  Google Scholar 

  51. Brubaker, RF, Halpin, JA: Open-angle glaucoma associated with topical administration of flurandrenolide to the eye. Mayo Clin Proc 50:322, 1975.

    PubMed  CAS  Google Scholar 

  52. Ramsell, TG, Bartholomew, RS, Walker, SR: Clinical evaluation of clobetasone butyrate: a comparative study of its effects in postoperative inflammation and on intraocular pressure. Br J Ophthal 64:43, 1980.

    Article  CAS  Google Scholar 

  53. Dunne, JA, Travers, JP: Double-blind clinical trial of topical steroids in anterior uveitis. Br J Ophthal 63:762, 1979.

    Article  CAS  Google Scholar 

  54. Eilon, LA, Walker, SR: Clinical evaluation of clobetasone butyrate eye drops in the treatment of anterior uveitis and its effect on intraocular pressure. Br J Ophthal 65:644, 1981.

    Article  CAS  Google Scholar 

  55. Bedrossian, RH, Eriksen, SP: The treatment of ocular inflammation with medrysone. Arch Ophthal 99:184, 1969.

    Google Scholar 

  56. Spaeth, GL: Hydroxymethylprogesterone. An anti-inflammatory steroid without apparent effect on intraocular pressure. Arch Ophthal 75:783, 1966.

    PubMed  CAS  Google Scholar 

  57. Dorsch, W, Thygeson, P: The clinical efficacy of medrysone, a new ophthalmic steroid. Am J Ophthal 65:74, 1968.

    PubMed  CAS  Google Scholar 

  58. Mindel, JS, Tavitian, HO, Smith, H Jr, Walker, EC: Comparative ocular pressure elevation by medrysone, fluorometholone, and dexamethasone phosphate. Arch Ophthal 98:1577,1980.

    PubMed  CAS  Google Scholar 

  59. Green, K, Cheeks, L, Slagle, T, Phillips, CI: Interaction between progesterone and mifepristone on intraocular pressure in rabbits. Curr Eye Res 8:317, 1989.

    Article  PubMed  CAS  Google Scholar 

  60. Fairbairn, WD, Thorson, JC: Fluorometholone. Anti-inflammatory and intraocular pressure effects. Arch Ophthal 86:138, 1971.

    PubMed  CAS  Google Scholar 

  61. Akingbehin, AO: Comparative study of the intraocular pressure effects of fluorometholone 0.1% versus dexamethasone 0.1%. Br J Ophthal 67:661, 1983.

    Article  CAS  Google Scholar 

  62. Morrison, E, Archer, DB: Effect of fluorometholone (FML) on the intraocular pressure of corticosteroid responders. Br J Ophthal 68:581, 1984.

    Article  CAS  Google Scholar 

  63. Stewart, RH, Kimbrough, RL: Intraocular pressure response to topically administered fluorometholone. Arch Ophthal 97:2139, 1979.

    PubMed  CAS  Google Scholar 

  64. Kass, M, Cheetham, J, Duzman, E, Burke, PJ: The ocular hypertensive effect of 0.25% fluorometholone in corticosteroid responders. Am J Ophthal 102:159, 1986.

    Article  PubMed  CAS  Google Scholar 

  65. Wilhemi, E: Experimental and clinical investigation of a non-hormonal anti-inflammatory eye ointment. Ophthal Res 5:253, 1973.

    Article  Google Scholar 

  66. Gieser, DK, Hodapp, E, Goldberg, I, et al: Flurbiprofen and intraocular pressure. Ann Ophthal 13:831, 1981.

    PubMed  CAS  Google Scholar 

  67. Espildora, J, Vicuna, P, Diaz, E: Cortisone- induced glaucoma: a report on 44 affected eyes. J Fr Ophthal 4:503, 1981.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophtalmology, Duke University Medical Center, Durham, NC, 27710, USA

    Prof. Dr. M. Bruce Shields

  2. Direktor der Universitäts-Augenklinik Köln, Joseph-Stelzmann-Straße 9, 50931, Köln, Deutschland

    Prof. Dr. Günter Karl Krieglstein

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  1. Prof. Dr. M. Bruce Shields
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  2. Prof. Dr. Günter Karl Krieglstein
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© 1993 Springer-Verlag Berlin Heidelberg

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Shields, M.B., Krieglstein, G.K. (1993). Steroidglaukom. In: Glaukom. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77053-1_20

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  • DOI: https://doi.org/10.1007/978-3-642-77053-1_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77054-8

  • Online ISBN: 978-3-642-77053-1

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