Skeletal muscle is one of the best characterized cell types in multicellular eucaryotic animals and is a striking example of the relationship between structural organization and differentiated function. Skeletal muscle has been the subject of intense cell biological and biochemical investigations that have led to a detailed understanding of the molecular basis of contraction. In recent years, there has been progress in studies of the embryological origin of skeletal muscle cells and in related studies on the molecular genetic mechanisms that regulate skeletal muscle cell differentiation and the expression of contractile protein genes. This recent progress has made the skeletal muscle a paradigm for understanding the fundamental molecular and genetic mechanisms of cellular differentiation.
KeywordsMyosin Heavy Chain Thin Filament Thick Filament Body Wall Muscle Myoblast Differentiation
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