Advertisement

Development pp 165-176 | Cite as

Circadian Rhythms of Neurospora

  • Stuart Brody

Abstract

The phenomena of circadian rhythms, sometimes called biological clocks, may seem out of place for a book devoted to development. The reasons are clear: biological clocks are often characterized in adult organisms and not in developing systems; and biological clocks show periodic functions whereas developmental systems are basically aperiodic. Both types of phenomena are temporal, however. This chapter, although basically devoted to the facts and strategies in the clock field, will also attempt to illustrate the connection between clocks and development. It will point out how an understanding of the mechanism of the clock and/or its input and output pathways, can be useful to the understanding of developmental events, cell cycle control, and responses to various environmental stimuli. It will also attempt to show how genetic and biochemical techniques, and combinations thereof, have been employed to probe the mechanism that is responsible for a given phenotype.

Keywords

Circadian Rhythm Circadian Clock Neurospora Crassa Temperature Compensation Biological Clock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Edmunds JLN (1988) Cellular and molecular bases of biological clocks. Springer, Berlin Heidelberg New York.Google Scholar
  2. Feldman JF, Dunlap JC (1983) Neurospora crassa: a unique system for studying circadian rhythms. Photochem Photobiol 7:319–368.Google Scholar
  3. Hall JC, Rosbash M (1987) Genes and biological rhythms. Trends Genet 3:185–191.CrossRefGoogle Scholar
  4. Lakin-Thomas P, Coté G, Brody S (1990) Circadian rhythms in Neurospora crassa: biochemistry and genetics. Crit Rev Microbiol 17:365–416.PubMedCrossRefGoogle Scholar
  5. Morse DS, Fritz L, Hastings JW (1990) What is the clock? Translational regulation of circadian bioluminescence. TIBS 15:262–265.PubMedGoogle Scholar
  6. Sweeney BM (1976) Circadian rhythms, definition, and general characterization. In: Hastings JW, Schweiger H(eds) The molecular basis of circadian rhythms. Dahlem Konferenzen, Berlin, pp 77–83.Google Scholar
  7. 2.
    Borgeson CE, Bowman BJ (1985) Blue light-reducible cytochromes in membrane fractions from Neurospora crassa. Plant Physiol 78:433–437.PubMedCrossRefGoogle Scholar
  8. Francis CD, Sargent ML (1979) Effects of temperature perturbations on circadian conidiation in Neurospora. Plant Physiol 64:1000–1004.PubMedCrossRefGoogle Scholar
  9. Gardner GF, Feldman JF (1981) Temperature compensation of circadian period length in clock mutants of Neurospora crassa. Plant Physiol 68:1244–1248.PubMedCrossRefGoogle Scholar
  10. Lakin-Thomas P, Brody S (1985) Circadian rhythms in Neurospora crassa: interactions between clock mutations. Genetics 109:49–66.PubMedGoogle Scholar
  11. Muñoz V, Brody S, Butler WL (1974) Photoreceptor pigment for blue light responses in Neurospora crassa. Biochem Biophys Res Commun 58:322–327.PubMedCrossRefGoogle Scholar
  12. Paietta J, Sargent ML (1983) Isolation and characterization of light-insensitive mutants of Neurospora crassa. Genetics 104:11–21.PubMedGoogle Scholar
  13. Russo VEA (1988) Blue light induces circadian rhythms in the bd mutant of Neurospora: double mutants bd, wc-1 and bd, wc-2 are blind. J Photochem Photobiol 2:59–65.CrossRefGoogle Scholar
  14. Sargent ML, Briggs WR (1967) The effects of light on a circadian rhythm of conidiation in Neurospora. Plant Physiol 42:1504–1510.PubMedCrossRefGoogle Scholar
  15. 3.
    Coté GG, Brody S (1987) Circadian rhythms in Neurospora crassa: membrane composition of a mutant defective in temperature compensation. Biochim Biophys Acta 898:23–36.PubMedCrossRefGoogle Scholar
  16. Dunlap JC, Feldman JF (1988) On the role of protein synthesis in the circadian clock of Neurospora crassa. Proc Natl Acad Sci USA 85:1096–1100.PubMedCrossRefGoogle Scholar
  17. Loros JJ, Feldman JF (1986) Loss of temperature compensation of circadian period length in the frq-9 mutant of Neurospora crassa. J Biol Rhythms 1:187–198.PubMedCrossRefGoogle Scholar
  18. Loros JJ, Richman A, Feldman JF (1986) A recessive circadian clock mutation at the frq locus of Neurospora crassa. Genetics 114:1095–1110.PubMedGoogle Scholar
  19. Mattern DL, Forman LR, Brody S (1982) Circadian rhythms in Neurospora crassa: a mutation affecting temperature compensation. Proc Natl Acad Sci USA 79:825–829.PubMedCrossRefGoogle Scholar
  20. McClung CR, Fox BA, Dunlap JC (1989) The Neurospora clock gene frequency shares a sequence with the Drosophila clock gene period. Nature 339:558–562.PubMedCrossRefGoogle Scholar
  21. 4.
    Hochberg ML, Sargent ML (1974) Rhythms of enzyme activity associated with circadian conidiation in Neurospora crassa. J Bacteriol 120:1164–1175.PubMedGoogle Scholar
  22. Loros JJ, Donome SA, Dunlap JC (1989) Molecular cloning of genes under control of the circadian clock in Neurospora. Science 243:385–388.PubMedCrossRefGoogle Scholar
  23. Roeder PE, Sargent ML, Brody S (1982) Circadian rhythms in Neurospora crassa: oscillations in fatty acids. Biochemistry 21:4909–4916.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Stuart Brody

There are no affiliations available

Personalised recommendations