Introductory Remarks. The Initiation of Eukaryotic DNA Replication and Its Control
Interactions of peptide growth factors with their receptors on the cell surface induce quiescent mammalian cells to enter the cell cycle. The signals received are transmitted to their intracellular targets mainly by a series of phosphorylation events with p34cdc2 and related protein kinases as primary participants as well as cyclin proteins that regulate the activity of the kinases (see E. Nigg and coworkers, this Vol., p 147). But other enzyme systems may also participate in signal transmission as, for example components of the ubiquitin-dependent protein degradation pathway (see S. Jentsch et al., this Vol., p. 177).
KeywordsReplication Fork Replication Initiation Introductory Remark Initiator Protein Palindromic Element
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