Abstract
Interactions of peptide growth factors with their receptors on the cell surface induce quiescent mammalian cells to enter the cell cycle. The signals received are transmitted to their intracellular targets mainly by a series of phosphorylation events with p34cdc2 and related protein kinases as primary participants as well as cyclin proteins that regulate the activity of the kinases (see E. Nigg and coworkers, this Vol., p 147). But other enzyme systems may also participate in signal transmission as, for example components of the ubiquitin-dependent protein degradation pathway (see S. Jentsch et al., this Vol., p. 177).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andrews BJ (1992) Dialogue with the cell cycle. Nature 355:393–394
Bell SP & Stillman B (1992) ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357:128–134
Bow JJ & Laskey RA (1986) Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs. Cell 47:577–587
Borowiec JA & Hurwitz J (1988) Localized melting and structural changes in the SV40 origin of replication induced by T antigen. EMBO J 7:3149–3158
Bramhill D & Romberg A (1988) A model for initiation at origins of DNA replication. Cell 54:915–918
Burhans WC, Vassilev LT, Caddie MS, Heintz NH & DePamphilis ML (1990) Identification of an origin of bidirectional DNA replication in mammalian chromosomes. Cell 62:955–965
Cook PR (1991) The nucleoskeleton and the topology of replication. Cell 66:627–635
Cox LS & Laskey RA (1991) DNA replication occurs at discrete sites in the pseudonuclei assembled from purified DNA. Cell 66:271–275
Crevel G & Cotterill S (1991) DNA replication in cell-free extracts from Drosophila melano- gaster. EMBO J 10:4361–4369
Fanning E & Knippers R (1992) Structure and function of simian virus 40 large T antigen. Ann Rev Biochem 61:55–85
Gasser SM (1991) Replication origins, factors and attachment sites. CUIT Opinion Cell Biol 3:407–413
Gille H, Egan JB, Roth A & Messer W (1990) The FIS protein binds and bends the origin of _ chromosomal DNA replication, ori C, of Escherichia coli. Nucl Acids Res 19:4167–4172
Gille H & Messer W (1991) Localized DNA melting and structural perturbations in the origin of replication, Ori C, of Escherichia coli in vitro and in vivo. EMBO J 10:1579–1584
Hamel PA, Gallie BL & Phillips RA (1992) The retinoblastoma protein and the cell cycle. Trends Genet 8:180–185
Hamlin IL, Vaughn JP, Dijkwel PA, Leu TH & Ma C (1991) Origins of replication: timing and chromosomal position. Curr Opinion Cell Biol 3:414–421
Heinzel SS, Krysan PJ, Tran CT & Calos MP (1991) Autonomous DNA replication in human cells is affected by the size and the source of the DNA. Mol Cell Biol 11:2263–2272
Herschman HR (1991) Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 60:281–319
Huberman JA & Riggs AD (1968) On the mechanism of DNA replication in mammalian chromosomes. J Mol Biol 32:327–341
Komberg A & Baker JA (1992) DNA replication. 2nd edn. WH Freeman, New York
Krysan PJ & Calos MP (1991) Replication initiates at multiple locations on an autonomously replicating plasmid in human cells. Mol Cell Biol 11:1464–1472
Marahrens Y & Stillman B (1992) A yeast chromosomal origin of DNA replication defined by multiple functional elements. Science 255:817–823
Maundrell K, Hutchinson A & Shall S (1988) Sequence analysis of ARS elements in fission yeast. EMBO J 7:2203–2209
Newport J (1987) Nuclear reconstitution in vitro: stages of assembly around protein-free DNA. Cell 48:205–217
Proud CG (1992) Protein phosphorylation in translational control. CUIT Top Cell Regul 32:243–369
Skarstad K, Baker TA & Komberg A (1990) Strand separation required for the initiation of replication at the chromosomal origin of E. coli is facilitated by a distant RNA-DNA hybrid. EMBO J 9:2341–2348
Taljanidisz J, Popowski J & Sarkar N (1989) Temporal order of gene replication in Chinese hamster ovary cells. Mol Cell Biol 9:2881–2889
Umek RM & Kowalski D (1988) The ease of DNA unwinding as a determinant of initiation of yeast replication origins. Cell 52:559–567
Von Meyenburg K & Hansen FG (1987) Regulation of chromosome replication. In: Neidhardt FC (ed) Escherichia coli and Salmonella typhimurium. Cellular and molecular biology. Am Soc Microbiol, Washington, DC, pp 1555–1577
Wessel R, Schweizer J & Stahl H (1992) Simian virus 40 T-antigen helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication. J Virol 66:804–815
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Knippers, R., Ruff, J. (1993). Introductory Remarks. The Initiation of Eukaryotic DNA Replication and Its Control. In: Fanning, E., Knippers, R., Winnacker, EL. (eds) DNA Replication and the Cell Cycle. Colloquium der Gesellschaft für Biologische Chemie, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77040-1_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-77040-1_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77042-5
Online ISBN: 978-3-642-77040-1
eBook Packages: Springer Book Archive