Pathophysiologie — Kontraktile Proteine

  • H. Katus
Part of the Aktuelle Therapieprinzipien in Kardiologie und Angiologie book series (THERAPIEPRINZ.)


Eine vermehrte hämodynamisehe Belastung kompensiert das Herz auf zellulärer Ebene durch eine Größenzunahme der Myozyten und entsprechende Massenzunahme intrazellulärer Moleküle (Vliegen et al. 1987; Campbell et al. 1989). Diese myokardiale Hypertrophie ist jedoch kein uniform ablaufender Prozeß. Statt dessen wird die quantitative und qualitative Änderung intrakardialer Moleküle bei der Herzhypertrophie von einer Fülle von exogenen und endogenen Faktoren beeinflußt. So hängt das Ausmaß der Hypertrophie von der untersuchten Spezies (Rouleau et al. 1989), der intrakardialen Lokalisation der hypertrophierenden Myozyten (Vescovo et al. 1989) und der Art der Belastung ab (Moalic et al. 1981). Aber nicht nur das Ausmaß, sondern auch die Qualität der Hypertrophie ist je nach Spezies und Ursache der Hypertrophie verschieden (Moalic et al. 1981; Hamrell u. Low 1978). Daraus resultiert ein für die jeweilige Spezies sowie für die Art und das Ausmaß der Hypertrophie spezifische Isoformzusammensetzung kardialer Moleküle.


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© Springer-Verlag Berlin Heidelberg 1992

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  • H. Katus

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