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Membrane Defenses Against Attack by Complement and Perforins pp 115–140Cite as

Effects of the Membrane Attack Complex of Complement on Nucleated Cells

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 178))

Abstract

In the last quarter of the nineteenth century several workers described the heatlabile lytic action of serum on bacteria and erythrocytes, and it was these observations which led to the discovery of the complement system (Nuttal 1888; Bordet 1898; Ehrlich and Morgenroth 1899). These lytic activities were subsequently shown to be mediated by the final stage in the complement system, the membrane attack complex (MAC). Given this history it is therefore perhaps not surprising that, until very recently, the MAC was considered by the majority of immunologists to be a lytic entity, the sole role of which was kill target cells. The concept that the MAC might cause more subtle (and often more pathologically relevant) changes in target cells has only recently gained widespread acceptance. The concept is of particular relevance when the targets are nucleated and metabolically active, although important nonlethal changes may also be induced in non-nucleated cells (see Chap. 7).

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  1. Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, Wales, CF4 4XN, UK

    B. P. Morgan

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  1. Department of Veterans Affairs Medical Center, University of Utah School of Medicine, Salt Lake City, Utah, 84148, USA

    Charles J. Parker A. B., M.D. (Associate Professor of Medicine, Chief, Hematology Subsection) (Associate Professor of Medicine, Chief, Hematology Subsection)

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Morgan, B.P. (1992). Effects of the Membrane Attack Complex of Complement on Nucleated Cells. In: Parker, C.J. (eds) Membrane Defenses Against Attack by Complement and Perforins. Current Topics in Microbiology and Immunology, vol 178. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77014-2_8

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