The Effects of Complement Activation on Platelets

  • D. V. Devine
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 178)


The platelet is a blood element essential to the maintenance of hemostasis. In order to participate in the formation of a hemostatic plug, the platelet must be able to respond to an array of biochemical signals. These signals may arise from other platelets, endothelial cells, or activated proteins of the coagulation and kininogen pathways. The platelet also exhibits physiological responses to activated proteins of another cascade pathway, complement. The interaction of blood platelets with the complement system is the subject of this review.


Complement Activation Human Platelet Paroxysmal Nocturnal Hemoglobinuria Platelet Membrane Platelet Surface 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • D. V. Devine
    • 1
  1. 1.Department of PathologyUniversity of British ColumbiaVancouverCanada

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