Abstract
The complement system has evolved as the major humoral defense mechanism against infection, and complement activation products mediate many of the processes of inflammation (Müller-Eberhard 1988). For example, C3a and C5a are potent anaphylatoxins, C5a is the primary mediator of neutrophil Chemotaxis, and activation (C3b) and degradation (iC3b) fragments of C3 are critically important opsonins that are recognized by specific receptors on phagocytic cells (Ross and Medof 1985). The complement system can also mediate cell killing directly through formation of the membrane attack complex.
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© 1992 Springer-Verlag Berlin Heidelberg
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Parker, C.J. (1992). Regulation of Complement by Membrane Proteins: An Overview. In: Parker, C.J. (eds) Membrane Defenses Against Attack by Complement and Perforins. Current Topics in Microbiology and Immunology, vol 178. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77014-2_1
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DOI: https://doi.org/10.1007/978-3-642-77014-2_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77016-6
Online ISBN: 978-3-642-77014-2
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