Safe Limits of Hemodilution in Patients with Coronary Artery Disease
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Intentional hemodilution has been introduced into surgery because transfusions using donor blood are associated with significant risks. The appearance of acquired immunodeficiency syndrome (AIDS) and its possible transmission via transfusion, despite donor selection, is a very sensitive problem for patients and physicians . However, AIDS ist probably not the major problem, since the risk of non-A non-B hepatitis transmission is quantitatively more important. In addition, the evidence that transfusion of homologous blood can induce immunosuppression and thereby impair the host resistance of surgical patients is a new cause of concern . These problems with homologous transfusion have promoted the use of all techniques of autotransfusion. Among these, intentional hemodilution is the one which has probably enjoyed the greatest development, since it is the simplest and least expensive.
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