A Gene of Saccharomyces cerevisiae Probably Involved in the Coordination of Chromatin Replication and Cell Division
The exact duplication of the genetic material and its perfect segregation between the two products of cell division has to be tightly coordinated during the cell cycle. A number of genes involved in the orderly progression of events necessary for cell division have been identified in the yeast, Saccharomyces cerevisiae, by screening for mutants which under certain restrictive conditions (e.g. high temperature) stop to proliferate. Such cell division cycle (cdc) mutants arrest at certain stages of the cell cycle and show a “terminal phenotype” indicating which of the sequencial steps the mutated gene might be resposible for (for review see Pringle and Hartwell, 1981). In addition to genes and proteins absolutely essential for genome and cell duplication, the existence of functions bringing about valuable but not vital improvements for the precision of the process has to be assumed. Such genes will not be picked up by screening for conditionally lethal mutations.
KeywordsWild Type Cell Schizosaccharomyces Pombe Pedigree Analysis Chromosome Missegregation Cell Duplication
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- Pringle JR, Hartwell LH (1981) The Saccharomyces cerevisiae cell cycle. In: Strathern JN, Jones EW, Broach JR (eds) The molecular biology of the yeast Saccharomyces. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY pp97–142Google Scholar