Amiloride-Sensitive Na+ Transport Mechanisms

  • D. J. Benos
  • D. G. Warnock
  • J. B. Smith
Part of the Membrane Transport in Biology book series (MEMBRANE, volume 5)


The major extracellular cation in animals is Na+. Although intracellular ionic composition varies depending upon cell type and origin, in general the major intracellular fluid cations are K+ and Mg2+, with Na+ kept at relatively low levels. The maintenance of these differences in ionic activities across cell membranes results from active accumulation and extrusion of specific ions, as well as from the selective permeability characteristics of the membranes themselves. In addition, the interior of most animal cells is electrically negative with respect to the bathing medium. Thus, Na+ diffuses from the extracellular fluid, where its electrochemical potential is high, into cells, where there is a much lower Na+ electrochemical potential energy state. This tendency for net cellular accumulation is opposed by the actions of the (Na+ + K+)-activated ATPase pump.


Sodium Channel Apical Membrane Frog Skin Epithelial Sodium Channel Squid Axon 
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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • D. J. Benos
  • D. G. Warnock
  • J. B. Smith

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