Role of Cryptic Self Germline Encoded Ig Epitopes in the Selection of the T cell Repertoire

  • Jian-Jun Chen
  • Srinivas-Venkatesh Kaveri
  • Heinz Kohler
Conference paper
Part of the NATO ASI Series book series (volume 66)


Although complexes of self peptides and MHC are believed to play a role in T cell repertoire selection, it is unknown whether hypervariable Ig peptides are involved. Murine T cell lines and clones were generated against a hypervariable region peptide derived from a self germline encoded S107 VI antibody. These peptide-specific T cells do not respond to the intact S107 antibody, even when presented by a S107 B cell transfectant. The role of such cryptic epitopes in highly polymorphic self antigens in the T cell repertoire selection is discussed.


self-Ig T cell repertoire selection cryptic epitope 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Jian-Jun Chen
    • 1
  • Srinivas-Venkatesh Kaveri
    • 1
  • Heinz Kohler
    • 1
  1. 1.San Diego Regional Cancer CenterSan DiegoUSA

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