Role of Cryptic Self Germline Encoded Ig Epitopes in the Selection of the T cell Repertoire
Although complexes of self peptides and MHC are believed to play a role in T cell repertoire selection, it is unknown whether hypervariable Ig peptides are involved. Murine T cell lines and clones were generated against a hypervariable region peptide derived from a self germline encoded S107 VI antibody. These peptide-specific T cells do not respond to the intact S107 antibody, even when presented by a S107 B cell transfectant. The role of such cryptic epitopes in highly polymorphic self antigens in the T cell repertoire selection is discussed.
Keywordsself-Ig T cell repertoire selection cryptic epitope
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