Abstract
The interaction between Leishmania parasites and Th1 cells is investigated using a simple mathematical model of immunological responses and parasite population growth within the host. The model generates patterns of resistance and susceptibility to infection that mirror observed trends in experimental infections of mice and humans exposed to infection in areas of endemic transmission. The heterogeneity in outcome predicted by the model can arise either through differences in the values of the parameters that characterize the genetic background of the host or as a consequence of differences in the size of the infecting inoculum of the parasite. Detailed analyses of equilibrium states and of the time course of infection within a host suggest that a limitation in the availability of precursor T cells, as a consequence of high levels of recruitment into the activated pool, may play a significant role in the progression of infection in susceptible hosts.
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© 1992 Springer-Verlag Berlin Heidelberg
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Schweitzer, A.N., Swinton, J., Anderson, R.M. (1992). Complex Outcomes in Mouse Leishmaniasis: A Model for the Dynamics of the TH1 Response. In: Perelson, A.S., Weisbuch, G. (eds) Theoretical and Experimental Insights into Immunology. NATO ASI Series, vol 66. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76977-1_12
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DOI: https://doi.org/10.1007/978-3-642-76977-1_12
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