Computer Modelling of the Immune System: Who are the “Fruitori”?
Fruitore is an Italian word straight from the Latin (the verb fruor means to utilize with advantage, to metaphorically harvest the fruits. I use this uncommon foreign substantive because it happens to be the most concise and precise, as compared with the English and the French (exploitateur? utiliseur? jouisseur?). Having explained the word, my assignment is to convince the reader that every experimental immunologist is a potential fruitore of the models (and will become an actual one in the near future). This was unforeseeable in the past, and I would not have written this sentence one year ago. The following factors, of which this NATO-Gulbenkian workshop is the best proof, have played into my hands. a) Theoretical immunology has been experiencing a substantial boom during the past several years, thanks to many new groups the world over joining what had been a restricted club of friends. b) The focus of many models has become more precisely coincident with that of experiments performed and discussed in conventional (classical) laboratories. c) Only in part a consequence of a) and b), the immunologists are changing their traditional apartheidlike attitude towards the theorists.
KeywordsCellular Automaton affInity Maturation Italian Word Special Feeling High Dose Tolerance
Unable to display preview. Download preview PDF.
- 1.Jerne, N.K. (1974) Towards a network theory of the immune system. Ann. Immunol. ( Inst. Pasteur ) 125C, 373 ).Google Scholar
- 3.Janeway, C. (1989) Approaching the asymptote: Evolution and revolution in immunology. Cold SpringHarbor Symp. Quant. Biol. Volume LIV, 1.Google Scholar
- 5.Varela, F.J. (1988) Structural coupling and the origin of meaning in a simple cellular automaton. In The Semiotics of Cellular Communication in the Immune System, E.E. Sercarz, F. Celada, A.N. Mitchison, T.Tada (eds). Springer-Verlag, Berlin. pp. 151–161.Google Scholar
- 8.Celada, F., Seiden, P.E. (1992) A Computer Model of Cellular Interactions in the Immune System. Immun. Today (Feb.),Google Scholar
- 9.Seiden, P.E.,Celada, F. (1992) ( Submitted ), J. Theor. Biol.Google Scholar