Pseudomonas aeruginosa Exoenzyme S

  • J. Coburn
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 175)


Pseudomonas aeruginosa is an opportunistic pathogen that secretes a number of potential virulence factors. Two of these, exotoxin A and exoenzyme S, catalyze the transfer of the ADP-ribose moiety of NAD to proteins in eukaryotic cells. Exotoxin A catalyzes the ADP-ribosylation of elongation factor 2 (EF-2), leading to disruption of protein synthesis. It has been well characterized and is reviewed elsewhere in this volume. Exoenzyme S has been less thoroughly studied, but several lines of evidence suggest that it might play a role in pathogenesis. In preliminary experiments exoenzyme S appeared to be unselective in choice of substrate proteins, but recent work has shown that it preferentially ADP-ribosylates several of the low-molecular weight GTP-binding proteins. Furthermore, like cholera toxin, exoenzyme S requires a eukaryotic protein for enzymic activity.


Pseudomonas Aeruginosa Cholera Toxin Diphtheria Toxin Potential Virulence Factor Culture Supernatant Fluid 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1992

Authors and Affiliations

  • J. Coburn
    • 1
  1. 1.Department of Molecular Biology and MicrobiologyTufts University School of MedicineBostonUSA

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