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Entry of ADP-Ribosylating Toxins into Cells

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ADP-Ribosylating Toxins

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 175))

Abstract

A number of bacterial toxins exert their action by ADP-ribosylating proteins essential for normal cellular function. In all cases known the substrate of these enzymes is either located free in the cytosol or associated with the cytoplasmic side of the plasma membrane. A key to understanding intoxication is therefore to understand how the toxins enter cells and get access to their cytoplasmic targets.

The authors were supported by the Norwegian Cancer Society.

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  1. Department of Biochemistry, Institute for Cancer Research at the Norwegian Radium Hospital, Montebello, N-0310, Oslo 3, Norway

    I. H. Madshus & H. Stenmark

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  1. I. H. Madshus
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  1. Institut für Pharmakologie und Toxikologie, Universität des Saarlands, 6650, Homburg/saar, Germany

    Klaus Aktories

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Madshus, I.H., Stenmark, H. (1992). Entry of ADP-Ribosylating Toxins into Cells. In: Aktories, K. (eds) ADP-Ribosylating Toxins. Current Topics in Microbiology and Immunology, vol 175. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76966-5_1

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