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Postoperative Vaginal Irradiation by High-Dose-Rate Cobalt Afterloading in Stage I Endometrial Cancer: Experience from the Norwegian Radium Hospital

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Therapie des Endometriumkarzinoms

Abstract

Radiotherapy has been used in all its possible varieties as primary and adjuvant treatment of endometrial cancer. Still, the proper place of this treatment modality remains to be defined. Despite the large number of patients treated by a combination of surgery and radiotherapy, surprisingly there are no hard data showing improved survival in patients treated by radiotherapy [1,2]. However, adjuvant irradiation has been shown to reduce vaginal recurrences [2–4], and external pelvic irradiation decreases the risk of pelvic recurrences [5–7]. The prospective randomized trial, performed at The Norwegian Radium Hospital [5], showed clearly that external radiation therapy although decreasing local recurrence did not improve survival.

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References

  1. Jones HW III: Treatment of adenocarcinoma of the endometrium. Obstet Gynecol Survey 30: 147, 1975

    Article  Google Scholar 

  2. Berek JS, Hacker NF, Hatch KD, Young RC: Uterine corpus and cervical cancer, Curr Probl Cancer 12: 65, 1988

    Google Scholar 

  3. Lotocki RJ, Copeland IJ, DePetrillo AD et al: Stage I endometrial adenocarcinoma: Treatment results in 835 patients. Am J Obstet Gynecol 146: 141, 1983

    PubMed  CAS  Google Scholar 

  4. Reddy S, Lee Ms, Hendrickson FR: Pattern of recurrences in endometrial cancer and their management. Radiology 133: 737, 1979

    PubMed  CAS  Google Scholar 

  5. Onsrud M, Kolstad P, Normann T: Postoperative external pelvic irradiation in carcinoma of the corpus Stage I: A controlled clinical trial. Gynecol Oncol 4: 222–231, 1976

    Article  PubMed  CAS  Google Scholar 

  6. Salazar OM, Feldstein ML, DePapp EW et al: Endometrial carcinoma: Analysis of failures with special emphasis on the use of initial preoperative external pelvic irradiation. Int J Radiat Oncol Biol Phys 2: 1101, 1977

    Article  PubMed  CAS  Google Scholar 

  7. Kucera H, Vavra N, Weghaupt K: Benefit of external irradiation in pathologic Stage I endometrial carcinoma: A prospective clinical trial of 605 patients who received postoperative vaginal irradiation and additional pelvic irradiation in the presence of unfavorable prognostic factors. Gynecol Oncol 38: 99, 1990

    Article  PubMed  CAS  Google Scholar 

  8. Leibel SA, Wharam MD: Vaginal and para-aortic lymph node metastases in carcinoma of the endometrium. Int J Radiat Oncol Biol Phys 6: 893–914, 1980

    Article  PubMed  CAS  Google Scholar 

  9. Mandell L, Dattatreyudu N, Anderson L, Hilaris B: Postoperative vaginal radiation in endometrial cancer using remote afterloading technique. Int J Radiat Oncol Biol Phys 11: 473, 1985

    Article  PubMed  CAS  Google Scholar 

  10. Sorbe B, Smeds AC: Postoperative vaginal irradiation by a high dose rate afterloading technique in endometrial carcinoma Stage I. Acta Oncol 28: 679, 1989

    Article  PubMed  CAS  Google Scholar 

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© 1991 Springer-Verlag Berlin Heidelberg

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Vergote, I., Kjorstad, K., Abeler, V., Vossli, S. (1991). Postoperative Vaginal Irradiation by High-Dose-Rate Cobalt Afterloading in Stage I Endometrial Cancer: Experience from the Norwegian Radium Hospital. In: Kleine, W., Meerpohl, HG., Pfleiderer, A., Profous, C.Z. (eds) Therapie des Endometriumkarzinoms. AGO Arbeitsgemeinschaft für Gynäkologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76950-4_11

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  • DOI: https://doi.org/10.1007/978-3-642-76950-4_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-54571-2

  • Online ISBN: 978-3-642-76950-4

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