Serotonin — der wichtigste Neurotransmitter des Menschen?

  • Hans-Georg Baumgarten
Conference paper
Part of the Die Reihe duphar med communication wird herausgegeben von Wolfgang Wagner und Ulrike Evers, Hannover. book series (dmc)

Zusammenfassung

Die expansive Kollateralisierung aufsteigender serotonerger Axone aus den oberen Raphekernen (Steinbusch 1981) und die erhebliche Innervationsdichte in vielen telodienzephalen Zielgebieten (Lidov et al. 1980; Foote u. Morrison 1987; Berger et al. 1988; Lavoie u. Parent 1990) läßt vermuten, daß Sero tonin bedeutende Einflüsse auf praktisch alle zentralen Regulationssysteme ausüben kann (Vogt 1982). Serotonin ist kein Exekutivtransmitter in Hauptfunktionsschleifen des ZNS, sondern ein übergeordneter Modulator, der die Arbeitsweise anderer retikulärer Neurotransmittersysteme (cholinerg, noradrenerg, dopaminerg) an die Erfordernisse der Vigilanzsteuerung im Schlaf-Wach-Zyklus anpaßt und den Durchsatz von Sinnessystemafferenzen durch komplexe Netzwerke und den Durchschlag von motorischen und nichtmotorischen (assoziativen) Exekutivsystemen (glutamaterg, aspartaterg) in Haupterregungsschleifen kontrolliert (Baumgarten u. Lachenmayer 1985; Baumgarten 1991). Wir haben diese Eigenschaft des aufsteigenden Serotoninsystems als protektive Filterfunktion bezeichnet, die bedeutungslose Informationsmuster (Störgrößen) eliminiert, aber verhaltensrelevante, wichtige Afferenzmuster bahnt (über bedarfsgerechte Änderungen des Gleichgewichts hemmender und fördernder Einflüsse des Serotoninsystems an Zielneuronen).

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  • Hans-Georg Baumgarten

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