Skip to main content
SpringerLink
Log in

Altern und Transmitterfreisetzung — Funktionelle und therapeutische Konsequenzen

  • Conference paper
Demenz

  • 120 Accesses

Zusammenfassung

Die Leistungsfähigkeit des Zentralnervensystems wird in wesentlichem Maße von der Struktur und der Funktion der neuronalen synaptischen Konnektivität bestimmt. Störungen synaptischer Übertragungsprozesse sind von funktioneller Relevanz und beachtlicher pathogenetischer Bedeutung für neuropsychiatrische Erkrankungen. Deshalb hat die Erforschung der normalen und krankhaft veränderten synaptischen Übertragung sowie deren pharmakologische Beeinflußbarkeit seit langem besondere Aufmerksamkeit gefunden und bildet auch heute einen Schwerpunkt der neurobiologischen Forschung.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Adams I, Jones DG (1987) Effects of normal and pathological aging on brain morphology: Neurons and synapses. Curr Top Res Synapses 4:1–84

    CAS  Google Scholar 

  2. Arendt T, Bigl V, Tennstedt A, Arendt A (1984) Correlation between cortical plaque count and memorial loss in the nucleus basalis in Alzheimer’s disease. Neurosci Lett 48:81–85

    Article  PubMed  CAS  Google Scholar 

  3. Coyle JT, Price DL, de Lang MR (1983) Alzheimer’s disease: A disorder of cortical cholinergic innervation. Science 219:1184–1190

    Article  PubMed  CAS  Google Scholar 

  4. De Estable-Puig RF, Estable-Puig JF, Murthy MR von, Raduco-Thomas S (1986) On the pathogenesis and therapy of dementia of the Alzheimer type: Some neuropatholo-gical, biochemical, genetic and pharmacotherapeutic considerations. Prog Neuropsy-chopharmacol Biol Psychiatry 10:355–390

    Article  Google Scholar 

  5. Fischer HD, Endtricht AK, Giele M et al. (1985) Posthypoxic transmitter release from brain slices and behavioural consequences of hypoxia in rats and mice. Biomed Biochim Acta 44:1219–1228

    PubMed  CAS  Google Scholar 

  6. Gibson GE, Peterson C (1981) Aging decrease oxidative metabolism and the synthesis and release of acetylcholine. J Neurochem 37:978–984

    Article  PubMed  CAS  Google Scholar 

  7. Giurgea C (1982) The nootropic concept and its prospective implications. Drug Dev Res 2:441–446

    Article  Google Scholar 

  8. Greenberg LM, Weiss B (1979) Ability of aged rats to alter beta adrenergic receptors of brain in response to repeated administration of reserpine and desmethylimipramine. J Pharmacol Exp Ther 211:309–316

    PubMed  CAS  Google Scholar 

  9. Helmchen H (1988) Wirkungen und Wirksamkeit von Nootropika. Springer, Berlin Heidelberg New York Tokyo

    Book  Google Scholar 

  10. Meyer EM, Baker SP, Crewes FT, Larsen K (1985) Aging and acetylcholine-release from cortical synaptosomal and atrial minces. Soc Neurosci Abstr 11:980

    Google Scholar 

  11. Raiteri M, Bonanno G, Calderini G, Caviglia A, Marchi M, Maura G (1986) Calcium dependence of transmitter release in nerve endings isolated from the brain of aged rats. Soc Neurosci Abstr 12:271

    Google Scholar 

  12. Schmidt J, Fischer HD, Wustmann C (1988a) Strategies and new aspects in the pharmacology of drugs for the treatment of senile dementia. Drug Dev Res 14:251–262

    Article  Google Scholar 

  13. Schmidt J, Wustmann C, Rudolph E, Zschorn EM, Fischer HD (1988b) Effect of nootropic drugs on age-dependent changes in transmitter release. Drug Dev Res 14:293–295

    Article  Google Scholar 

Download references

Authors
  1. J. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. D. Fischer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrischen Klinik mit Poliklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6-10, D-8520, Erlangen, Deutschland

    Eberhard Lungershausen (Direktor) (Direktor)

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schmidt, J., Fischer, H.D. (1992). Altern und Transmitterfreisetzung — Funktionelle und therapeutische Konsequenzen. In: Lungershausen, E. (eds) Demenz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76932-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76932-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76933-7

  • Online ISBN: 978-3-642-76932-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation